ESTRO 2025 - Abstract Book

S3095

Physics - Inter-fraction motion management and offline adaptive radiotherapy

ESTRO 2025

Conclusion: Recognizing respiratory irregularities during treatment planning enables the selection of optimal rigid registration strategies to reduce residual positioning uncertainty. Enhancing alignment between 4D-CT and 4D-CBCT phase reconstruction algorithms offers additional potential to improve accuracy. Overall, positioning uncertainties remain within clinically acceptable margins, highlighting the effectiveness of current motion compensation techniques for most patients. Applying optimal rigid registration implementations could be utilized to reduce safety margins, enhancing normal tissue sparing or enabling further dose escalation to improve therapeutic outcomes.

Keywords: 4DCT, IGRT, irregular respiration

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Digital Poster Adaptive vs. non-adaptive proton therapy in esophageal cancer treatment planning: impact on mean heart dose and post-treatment mortality Vlad M Badiu, Esther Kneepkens, Dominique Reijtenbagh, Maaike Berbée, Richard Canters