ESTRO 2025 - Abstract Book

S3163

Physics - Inter-fraction motion management and offline adaptive radiotherapy

ESTRO 2025

Conclusion: IOE2.0 addresses the key limitations of IOE1.0 by improving VMAT planning speed and incorporating a multi-level priority system that enhances flexibility and reduces planner dependency. This streamlined approach consistently produces high-quality plans for hypofractionated whole breast radiotherapy, even in complex cases, demonstrating its clinical feasibility for online adaptive radiotherapy workflows.

Keywords: IOE 2.0, whole breast, hypofractionated

References: 1.

Murray Brunt, A., et al., Hypofractionated breast radiotherapy for 1 week versus 3 weeks (FAST-Forward): 5-year efficacy and late normal tissue effects results from a multicentre, non-inferiority, randomised, phase 3 trial. The Lancet, 2020. 395 (10237): p. 1613-1626. 2. Fogliata, A., et al., Intensity Modulated Therapy for Patients With Breast Cancer. Practical Guidelines and Tips for an Effective Treatment Planning Strategy. Adv Radiat Oncol, 2024. 9 (8): p. 101535.