ESTRO 2025 - Abstract Book

S3170

Physics - Inter-fraction motion management and offline adaptive radiotherapy

ESTRO 2025

Conclusion: SWOT provided a strategic overview essential for understanding how to maximize the benefits and minimize the risks of OAPT, facilitating a smoother transition to clinical adoption for this early-stage procedure. A broad-scale OAPT implementation will allow for completely new treatment schemes and bring other technologies and concepts into clinical reality.

Keywords: online adaptation, particle therapy, EPTN

References: [1] Albertini et al. PMB 2024. Doi: 10.1088/1361-6560/ad7cbd [2] ClinicalTrials.gov ID: NCT06310655

3283

Proffered Paper Effects of anatomical changes on CTV dose and NTCP and the benefit of replanning in photon and proton therapy of lung cancer patients. Djoya Hattu 1 , Vicki Taasti 1,2 , Daisy Emans 1 , Marije Velders 1 , Judith van der Stoep 1 , Anouk Vullings 1 , Maud van den Bosch 1 , Janou Buck 1 , Anke van der Salm 1 , Judith van Loon 1 , Dirk de Ruysscher 1 , Richard Canters 1 1 Department of Radiation Oncology (MAASTRO), GROW – School for Oncology and Reproduction, Maastricht University Medical Center, Maastricht, Netherlands. 2 Danish Centre for Particle Therapy, Aarhus University Hospital, Aarhus, Denmark Purpose/Objective: Adaptive radiotherapy protocols are labor-intensive and the clinical relevance with respect to treatment outcome is not always evident. With an increasing implementation of online adaptive treatment systems, the challenge lies in selecting the correct patients that benefit from replanning. In this study, we investigated the effects of anatomical changes on target and maximum organ-at-risk dose, and normal tissue complication probabilities (NTCP).