ESTRO 2025 - Abstract Book

S3178

Physics - Inter-fraction motion management and offline adaptive radiotherapy

ESTRO 2025

Conclusion: Margin reduction in combination with daily adaptation can maintain target dose, despite anatomical changes, whilst reducing dose to normal tissue. Furthermore, maintained target coverage was achieved also for unconventional beam geometries. Although the reduction in normal tissue dose was less consistent, this approach helped to shorten delivery time and reduce gantry occupation.

Keywords: online adaptive proton therapy, delivery speed

References: 1. Albertini, F., Czerska, K., Vazquez, M., Andaca, I., Bachtiary, B., Besson, R., Bolsi, A., Bogaert, A., Choulilitsa, E., Hrbacek, J., Jakobsen, S., Leiser, D., Matter, M., Mayor, A., Meier, G., Nanz, A., Nenoff, L., Oxley, D., … Weber, D. (2024). First clinical implementation of a highly efficient daily online adapted proton therapy (DAPT) workflow. Physics in Medicine & Biology , 69 (21), 215030. https://doi.org/10.1088/1361-6560/ad7cbd 2. Matter, M., Nenoff, L., Meier, G., Weber, D. C., Lomax, A. J., & Albertini, F. (2019). Acta Oncologica Intensity modulated proton therapy plan generation in under ten seconds Intensity modulated proton therapy plan generation in under ten seconds . https://doi.org/10.1080/0284186X.2019.1630753