ESTRO 2025 - Abstract Book

S3252

Physics - Intra-fraction motion management and real-time adaptive radiotherapy

ESTRO 2025

Conclusion: The patient specific model predicted GTV and pancreas-head contour in intra-fraction triggered kV images with mean accuracy better than 1 mm, indicating the potential for clinical real-time application. Further data collection is planned for training and evaluation across a broader patient/treatment mix.

Keywords: real-time localisation, markerless tracking

References: 1. Ilic M, Ilic I. Epidemiology of pancreatic cancer. World J Gastroenterol 2016:22 https://doi.org/10.3748/wjg.v22.i44.9694

2. Chuong et al. Stereotactic MR-guided on-table adaptive radiation therapy (SMART) for borderline resectable and locally advanced pancreatic cancer: A multi-center, open-label phase 2 study. Radiother & Oncol 2023 https://doi.org/10.1016/j.radonc.2023.110064 3. Rudra et al. High dose Adaptive MRI guided radiation therapy improves overall survival of inoperable pancreatic cancer. Int.J.Radiat.Oncol.Physics 2017 10.1016/j.ijrobp.2017.06.1042

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Digital Poster Correlation of lung tumor motion with clinical covariates: a retrospective evaluation of CyberKnife Synchrony data Ashlesha Gill 1 , Pejman Rowshan Farzad 1 , Mahsheed Sabet 2,1 , Nicholas Bucknell 2 , Milad Mirzaei 2 1 School of Physics, Mathematics and Computing, The University of Western Australia, Perth, Australia. 2 Radiation Oncology, Sir Charles Gairdner Hospital, Perth, Australia Purpose/Objective: For lung cancer patients ineligible for surgery, stereotactic body radiation therapy (SBRT) is the standard treatment. These patients often present with comorbidities such as chronic obstructive pulmonary disease (COPD), interstitial lung disease (ILD), and asthma, which impair lung function and increase their susceptibility to severe radiation-