ESTRO 2025 - Abstract Book

S3285

Physics - Intra-fraction motion management and real-time adaptive radiotherapy

ESTRO 2025

Conclusion: IPRO uses a more accurate dose delivery model, based on 4DDC, for treatment plan optimization compared to 4DRO. This more accurate model can mitigate the interplay effect and more effectively spare OARs for methods with comparable target coverage, even when the evaluation data is unseen during optimization. The result indicates that implementing IPRO methods would decrease the reliance on motion management techniques during delivery and further increase the potential of hypofractionated treatments.

Keywords: interplay, robustness, optimization

References: [1] Zhang et al., A survey of practice patterns for real-time intrafractional motion-management in particle therapy , Physics and Imaging in Radiation Oncology, Volume 26, April 2023, Pages 100439 [2] Duetschler et al., Synthetic 4DCT({MRI}) lung phantom generation for 4D radiotherapy and image guidance investigations , Medical Physics, Volume 49, Issue 5, May 2022, Pages 2890-2903 [3] Engwall et al., 4D robust optimization including uncertainties in time structures can reduce the interplay effect in proton pencil beam scanning radiation therapy , Volume 45, Issue 9, September 2018, Pages 4020-4029

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Digital Poster Commissioning and Clinical Experience of Comprehensive Motion Management in MR-Guided Radiotherapy Stefanos Diamantopoulos 1 , Kayleigh Brook 1 , Joan Chick 1 , Hosna Mohammad 2 , Adam Mitchell 1 , Alex Dunlop 1 , Simeon Nill 1 , Uwe Oelfke 1 1 Joint Department of Physics, The Royal Marsden NHS Foundation Trust and Institute of Cancer Research, London, United Kingdom. 2 Radiotherapy, The Royal Marsden NHS Foundation Trust, London, United Kingdom