ESTRO 2025 - Abstract Book

S3515

Physics - Optimisation, algorithms and applications for ion beam treatment planning

ESTRO 2025

Results:

The result of employing of effective LET approach to the composite NPC plan is shown in Figure 1 . In the top row, a high LET is noted in the oral cavity of the effective LET heat map, and a comparison with the phase 1 and 2 LETs revealed that the high LET in phase 1 is the main contributing cause. Similar, in the bottom row, a high effective LET in the optic chiasm can also be attributed the LET from phase 1 rather than 2. Conclusion: This tool can help the clinician and dosimetrist to better assess and optimize the LET of a sequential boost proton therapy plan. The effective LET computed in the composite plan can potentially be optimized as a future work, to yield a better overall plan quality.

Keywords: Proton therapy, LET, RBE

3004

Digital Poster Simulation and optimization of treatment schedule for multi-gantry heavy ion therapy center Ethan D. Stolen 1 , Sridhar Yaddanapudi 2 , Helen Qian 1 , Sang Kyun Yoo 3 , Bo Lu 2 , Justin C. Park 2 , Jun Tan 2 , Xiaoying Liang 2 , Keith M. Furutani 2 , Chris J. Beltran 2 , James J. Sohn 1 1 Radiation and Cellular Oncology, University of Chicago, Chicago, USA. 2 Department of Radiation Oncology, Mayo Clinic Florida, Jacksonville, USA. 3 Department of Radiation Oncology, Heavy Ion Therapy Research Institute, Yonsei University, Seoul, Korea, Republic of