ESTRO 2025 - Abstract Book

S3534

Physics - Optimisation, algorithms and applications for ion beam treatment planning

ESTRO 2025

Conclusion: The results of this study confirm the feasibility of the use of DirectSPR and Mono+ images generated by the Syngo.via software as input to the Raystation TPS for proton dose calculation. Although preliminary, these findings support the reduction of the 3.5% clinical density uncertainty enabled by the implementation of DECT as suggested by many authors[6].

Keywords: density uncertainty, proton therapy

References: [1] H. Paganetti. «Relative biological effectiveness (RBE) values for proton beam therapy. Variations as a function of biological endpoint, dose, and linear energy transfer». [2] C. Antunes et al. “Pros and Cons of Dual-Energy CT Systems:"One Does Not Fit All".” [3] E. Bär et al. «The potential of dual-energy CT to reduce proton beam range uncertainties». [4] U. Schneider et al. “The calibration of CT Hounsfield units for radiotherapy treatment planning”. [5] A. Christopher et al. “Practical considerations in the calibration of CT scanners for proton therapy”. [6] N. Peters et al. "Reduction of clinical safety margins in proton therapy enabled by the clinical implementation of dual-energy CT for direct stopping-power prediction."