ESTRO 2025 - Abstract Book

S3542

Physics - Optimisation, algorithms and applications for ion beam treatment planning

ESTRO 2025

Conclusion: LET-optimization consistently reduced LETd to optic structures compared to the conventional reference plans, notably resulting in lower variable RBE-weighted doses. This approach is a promising strategy that may reduce the risk of optic neuropathy following proton therapy.

Keywords: LET-optimization, RBE-models, sinonasal cancer