ESTRO 2025 - Abstract Book

S3572

Physics - Optimisation, algorithms and applications for ion beam treatment planning

ESTRO 2025

Conclusion: While there are not enough proton treatment facilities to provide proton therapy to every patient who would benefit, there is a need for combined plans to allow certain patients to benefit partially from the improved dose distribution of proton plans. We present a first decision support tool that allows the decision maker to directly navigate the Pareto front of the mixed plans and compare the DVH curves for the respective navigated photon and proton plans as well as the mixed plan. The decision maker can interactively change the number of proton fractions and observe the resulting change in the objective values and DVH curves.

Keywords: multiobjective, decision-making, proton-photon

References: [1] Allmendinger, R., Ehrgott, M., et al. (2017). doi.org/10.1002/mcda.1599 [2] Thieke, C., Küfer, K. H., et al. (2007). doi.org/10.1016/j.radonc.2007.06.020 [3] Wheeler, P. A., Chu, M., et al. (2019). Doi.org/10.1016/j.radonc.2019.08.001 [4] Kamal-Sayed, H., Ma, J., et al. (2018). doi.org/10.1002/mp.13239 [5] Chen, W., Unkelbach, J., et al. (2012). doi.org/10.1088/0031-9155/57/3/591 [6] Unkelbach, J., Fabiano, et al. (2021). doi.org/10.5167/uzh-210965 [7] Hartikainen, M., Miettinen, K., & Klamroth, K. (2019). doi.org/10.1016/j.ejor.2018.11.038 [8] Collicott, C., Bonacker, E., et al. (2021) doi.org/10.1002/mcda.1768

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Digital Poster The NOVO project – proton beam range verification in clinical settings Anna M Bekkevoll 1,2 , Kristian S Ytre-Hauge 1 , Camilla H Stokkevåg 1,2 , Sander B Thu 1 , Liv B Hysing 1,2 , Toni Kögler 3,4 , Ilker Meric 5 1 Department of Physics and Technology, University of Bergen, Bergen, Norway. 2 Department of Oncology and Medical Physics, Haukeland University Hospital, Bergen, Norway. 3 OncoRay – National Center for Radiation Research in Oncology, Medical Faculty and University Hospital Carl Gustav Carus, TUD Dresden University of Technology, Helmholtz-Zentrum Dresden, Rossendorf, Dresden, Germany. 4 Helmholtz-Zentrum Dresden Rossendorf, Institute of Radiooncology OncoRay, Dresden, Germany. 5 Department of Computer Science, Electrical Engineering and Mathematical Sciences, Western Norway University of Applied Sciences, Bergen, Norway Purpose/Objective: The NOVO project -Next Generation Imaging for Real-Time Dose Verification Enabling Adaptive Proton Therapy- aims to enable proton range verification through the detection of secondary radiation produced during treatment. Proton therapy faces challenges caused by patient mispositioning, movements, tumor shrinkage or other anatomical changes during treatment. Consequently, there is some uncertainty in the location of the Bragg peak and thus the delivered dose. During treatment, secondary radiation is produced in form of prompt gamma rays (PG) and fast neutrons (FN). The NOVO project is developing the NOVO Compact Detector Array (NOVOCoDA), capable of detecting both PGs and FNs. With this, we aim to accurately determine the location of the Bragg peak, allowing for dose reconstruction, and ultimately facilitating real-time dose verification and adaptive proton therapy. This study employs Monte Carlo simulations to study FN production, in order to adapt the NOVO concept to different patient groups. Material/Methods: Proton treatment plans were generated using the Eclipse treatment planning system for patients with brain, prostate, and lung cancer. Treatment plans were exported, and further simulated using the FLUKA Monte Carlo