ESTRO 2025 - Abstract Book

S3716

Physics - Radiomics, functional and biological imaging and outcome prediction

ESTRO 2025

References: 1. Rapidis AD, Dijkstra PU, Roodenburg JLN, Rodrigo JP, Ronald A, Strojan, et al. Trismus in patients with head and neck cancer: Etiopathogenesis, diagnosis and management. Clin Otolaryngology. 2015;40(6):516-526. 2. Sun Y, Yu XL, Luo W, Lee WM, Wee TS, Lee N, et al. Recommendation for a contouring method and atlas of organs at rick in nasopharyngeal carcinoma patients receiving intensity-modulated radiotherapy. Radiotherapy Oncol . 2014;110(3):390-397. 3. Tough DN, Levendag PC, Voet P, van der Est H, Noever I, de Kruijf W, et al. Trismus in patients with oropharyngeal cancer: relationship with does in structures of mastication apparatus. Head Neck . 2008;30(5):622-630.

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Digital Poster Diffusion Weighted Imaging Acquired on MR-LINACs in MR-guided Radiotherapy: A Systematic Review Jing Yuan 1 , Darren MC Poon 2 , Oi Lei Wong 1 , Cindy Xue 1 , Bin Yang 3 1 Research Department, Hong Kong Sanatorium and Hospital, Happy Valley, Hong Kong. 2 Comprehensive Oncology Centre, Hong Kong Sanatorium and Hospital, Happy Valley, Hong Kong. 3 Medical Physics Department, Hong Kong Sanatorium and Hospital, Happy Valley, Hong Kong Purpose/Objective: Diffusion-weighted imaging (DWI) is gaining increasing interests in MR-guided radiotherapy (MRgRT), particularly with the capability of acquiring DWI on MR-linear accelerators (MR-LINACs). This systematic review aims to summarize and evaluate the utilization of DWI acquired on MR-LINACs in the context of MRgRT. The review will explore its technical development and assessment, challenges, and current clinical utilization and findings in MRgRT. Material/Methods: A comprehensive literature search was conducted across PubMed, Scopus, and Web-of-Science, for studies published up to April-2024 following the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) guidelines. Inclusion criteria comprised original articles, both technical and clinical, that acquired and utilized DWI on MR-LINACs. Other article types like reviews and abstracts were excluded. Studies that used DWI solely acquired on diagnostic scanners, even for MRgRT, were excluded. Data were extracted regarding study design, patient populations, imaging protocols, technical/clinical assessment, outcomes and other relevant information. Data extraction and quality assessment were performed independently by three reviewers, with disagreements resolved through discussion.

Results:

A total of 23 studies, all prospective, were included (Figure. 1), comprising 18 technical and 5 clinical studies, involving 292 patients with various cancers. Sixteen and 7 studies acquired DWI on 1.5T and 0.35T MR-LINACs,