ESTRO 2025 - Abstract Book

S3737

Physics - Radiomics, functional and biological imaging and outcome prediction

ESTRO 2025

Conclusion: We investigated the α/β ratio and EUD volume parameter, n , of the rectum for acute proctitis risk prediction. Using a unique dataset of patients treated with 3 different fractionation schedules, who reported the same types of patient reported outcomes, we found moderate-to-high dose volumes of importance and a relatively low sensitivity to fractionation. With appropriate α/β and n a common prediction model could be created for all three fractionation schedules.

Keywords: acute proctitis, NTCP

References: [1] Sinzabakira, F., Brand, V., Heemsbergen, W.D., Incrocci, L. Acute and late toxicity patterns of moderate hypo fractionated radiotherapy for prostate cancer: A systematic review and meta-analysis. Clin Transl Oncol 2023;40:100612.