ESTRO 2025 - Abstract Book

S3756

Physics - Radiomics, functional and biological imaging and outcome prediction

ESTRO 2025

Conclusion: Synthesizing PET images from MRI generated by deep learning model shows improvement in OS prediction and pCR assessment to support personalized treatment decisions.

Keywords: Deep Learning, Synthetic PET Images, MRI

References: 1. Chen R, Huang W, Huang B, Sun F, Fang B, editors. Reusing discriminators for encoding: Towards unsupervised image-to-image translation. Proceedings of the IEEE/CVF conference on computer vision and pattern recognition; 2020. 2. Lovinfosse P, Polus M, Van Daele D, Martinive P, Daenen F, Hatt M, et al. FDG PET/CT radiomics for predicting the outcome of locally advanced rectal cancer. 2018;45:365-75. 3. Shin J, Seo N, Baek S-E, Son N-H, Lim JS, Kim NK, et al. MRI radiomics model predicts pathologic complete response of rectal cancer following chemoradiotherapy. 2022;303(2):351-8.

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Digital Poster Unsupervised machine-learning identifies patient clusters associated to treatment response after SBRT in oligometastatic gynaecological cancer Savino Cilla 1 , Francesco Deodato 2 , Donato Pezzulla 2 , Carmela Romano 1 , Maura Campitelli 3 , Andrei Fodor 4 , Concetta Laliscia 5 , Fabio Trippa 6 , Vitaliana De Sanctis 7 , Edy Ippolito 8 , Martina Ferioli 9 , Francesca Titone 10 , Donatella Russo 11 , Vittoria Balcet 12 , Lisa Vicenzi 13 , Vanessa Di Cataldo 14 , Arcangela Raguso 15 , Gabriella Ferrandina 16 , Maria A Gambacorta 3 , Alessio G Morganti 9 , Gabriella Macchia 2 1 Medical Physics Unit, Responsible Research Hospital, Campobasso, Italy. 2 Radiation Oncology Unit, Responsible Research Hospital, Campobasso, Italy. 3 Radiation Oncology Unit, Fondazione Policlinico Universitario A. Gemelli IRCCS, Roma, Italy. 4 Department of Radiation Oncology, IRCCS San Raffaele Scientific Institute, Milano, Italy. 5 Department of Translational Medicine, University of Pisa, Pisa, Italy. 6 Radiation Oncology Center, S. Maria Hospital, Terni, Italy. 7 Radiation Oncology Unit, S. Andrea Hospital, Roma, Italy. 8 Department of Radiation Oncology, Campus Bio-Medico University, Roma, Italy. 9 Department of Experimental, Diagnostic and Specialty Medicine - DIMES, S. Orsola -Malpighi Hospital, Bologna, Italy. 10 Department of Radiation Oncology, University Hospital Udine, Udine, Italy. 11 Radiation Oncology Unit, Vito Fazzi Hospital, Lecce, Italy. 12 Radiation Oncology Department, Ospedale degli