ESTRO 2025 - Abstract Book

S3827

Physics - Radiomics, functional and biological imaging and outcome prediction

ESTRO 2025

values discriminated patients with toxicity beyond the best performing absolute EUD (from Dose-Surface Histogram, n=1 for incontinence/diarrhea, n=0.1 for proctitis).

In the higher EUD range (75th-percentile, EUD>45Gy for incontinence/diarrhoea, EUD>60Gy for proctitis), AUC from EUDs were 0.62/0.57/0.53 for incontinence/diarrhoea/proctitis, and 0.69/0.72/0.60 when using t-values.

Conclusion: The Functional-Discriminant Approach overcomes the reduction of the dose distribution to the DVH/DSH (which loses spatial information) and should be investigated further for other endpoints/cancers. On the considered population, the Functional-Discriminant Approach demonstrated that for late rectal toxicities, the spatial distribution of high-doses is more informative than the quantity of dose received.

Keywords: dose-patterns, functional data analysis, toxicity

References: Acknowledgements to REQUITE EU 7th FP GA 601826, RADprecise ERAPERMED2018-244 and JTC ERA PerMed 2020, PerPlanRT Project - Italian Ministry of Health ERP-2020-23671125

3496

Digital Poster Can perfusion MRI improve radiotherapy target delineation of glioblastoma? Patrick L.Y. Tang 1,2,3 , Marion Smits 1,2,4 , Remi A. Nout 3 , Caroline van Rij 1,3 , Cleo Slagter 1,3 , Annemarie T. Swaak Kragten 1,3 , Esther A.H. Warnert 1,2 , Alejandra Méndez Romero 1,3 1 Brain Tumor Center, Erasmus MC Cancer Institute, University Medical Center Rotterdam, Rotterdam, Netherlands. 2 Department of Radiology & Nuclear medicine, Erasmus MC, University Medical Center Rotterdam, Rotterdam,