ESTRO 2025 - Abstract Book

S3890

Radiobiology - Immuno-radiobiology

ESTRO 2025

that increasing the dose of radiation at the valley enhances tumor control 3 . To further understand macrophages’ impact, it is essential to analyze cytokine release and their differentiation and infiltration in spheroids. These findings underline the potential of 3D in vitro models to change preclinical research, offering an alternative to in vivo studies for evaluating radiotherapeutic strategies in glioblastoma treatment.

Keywords: macrophages, minibeam, spheroid

References: 1. Koksal Akbas, C. et al. Preclinical photon minibeam radiotherapy using a custom collimator: Dosimetry characterization and preliminary in-vivo results on a glioma model. Phys. Med. 124 , 103420 (2024). 2. Chen, M.-H., Liu, T.-Y., Chen, Y.-C. & Chen, M.-H. Combining Augmented Radiotherapy and Immunotherapy through a Nano-Gold and Bacterial Outer-Membrane Vesicle Complex for the Treatment of Glioblastoma. Nanomaterials 11 , 1661 (2021). 3. Fernandez-Palomo, C., Chang, S. & Prezado, Y. Should Peak Dose Be Used to Prescribe Spatially Fractionated Radiation Therapy?—A Review of Preclinical Studies. Cancers 14 , 3625 (2022).