ESTRO 2025 - Abstract Book

S3898

Radiobiology - Microenvironment

ESTRO 2025

Conclusion: CAFs do not undergo cell death after irradiation, but rather undergo senescence. After irradiation, CAFs maintain their ability to enhance HNSCC cell migration, suggesting CAFs preserve pro-tumorigenic characteristics after irradiation. Therefore, we selectively target radiation-induced senescent cells, in which senolytic drugs show significant promise. Combined, these findings lay the foundation for research into CAF-targeted therapies to improve radiotherapy efficacy.

Keywords: Cancer-associated fibroblasts, radioresistance

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Digital Poster Spatial atlas reveals the mechanism of resistance to neoadjuvant immunotherapy combined with radiotherapy in esophageal squamous cell carcinoma Xiaoyang Yin 1 , Kailun Xu 2 , Baosheng Li 3 1 Department of Radiation Oncology, The Affiliated Hospital of Qingdao University, Qingdao, China. 2 Department of Breast Surgery and Oncology (Key Laboratory of Cancer Prevention and Intervention, China National Ministry of Education, Key Laboratory of Molecular Biology in Medical Sciences), Cancer Institute, The Second Affiliated Hospital, Hangzhou, China. 3 Department of Radiation Oncology, Shandong Cancer Hospital and Institute, Shandong First Medical University and Shandong Academy of Medical Sciences, Jinan, China Purpose/Objective: Combination of immunotherapy and radiotherapy in neoadjuvant treatment is a promising approach in resectable esophageal squamous cell squamous (ESCC). Clinical studies showed good result, but there are still patients who are resistant to the treatment. In order to investigate the underlying mechanism of the resistance, we performed