ESTRO 2025 - Abstract Book

S3940

Radiobiology - Normal tissue radiobiology

ESTRO 2025

Keywords: erectile dysfunction, prostate cancer

References: [1] Oh JH, Kerns S, Ostrer H et al. Computational methods using genome-wide association studies to predict radiotherapy complications and to identify correlative molecular processes. Scientific Reports, 7: 43381, 2017. [2] Oh JH, Lee S, Thor M et al. Predicting the germline dependence of hematuria risk in prostate cancer radiotherapy patients. Radiotherapy and Oncology, 185:109723, 2023. [3] van Hilten A, Kushner SA, Kayser M et al. GenNet framework: interpretable deep learning for predicting phenotypes from genetic data. Communications Biology, 4:1094, 2021.

3207

Proffered Paper A focal duodenal radiation injury model for investigating duodenal and stool microbiome dynamics in acute and late phase radiation injury LeMoyne Habimana-Griffin 1 , Jerome Prusa 2 , Bin Wang 2 , Lori Strong 1 , Skye Fishbein 2 , Jie Ning 2 , Sammy Ramirez 2 , Kelsey Toth 3 , Blake Butler 2 , Francisco Reynoso 4 , Stephanie Markovina 1 , Matthew Ciorba 3 , Gautam Dantas 2 1 Radiation Oncology, Washington University School of Medicine in St. Louis, Saint Louis, USA. 2 Pathology-Lab & Genomic Medicine, Washington University School of Medicine in St. Louis, Saint Louis, USA. 3 Gastroenterology, Washington University School of Medicine in St. Louis, Saint Louis, USA. 4 Medical Affairs, Varian, a Siemens Healthineers Company, Palo Alto, USA Purpose/Objective: The duodenum is a key organ at risk during stereotactic ablative radiotherapy (SABR), and understanding mechanisms of duodenal radiation injury could reduce toxicities of SABR in the abdomen. The gut microbiome contributes to bowel radiation injury, however existing preclinical models either require surgical manipulation or do not recapitulate high dose conformal treatment fields used during SABR, which can confound microbiome studies.