ESTRO 2025 - Abstract Book

S3948

Radiobiology - Normal tissue radiobiology

ESTRO 2025

Conclusion: MRT demonstrates significant normal tissue sparing effects in the liver, inducing localized cell death with minimal overall tissue injury and an absence of liver fibrosis in the long term. These findings highlight the potential of SFRT for clinical translation by addressing the challenges of RT in the liver. Ongoing studies use IMC to investigate immune cell dynamics and tissue repair processes post-MRT. Further studies will also focus on evaluating SFRT's tumour control efficacy in HCC.

Keywords: RILD, liver regeneration, microenvironment

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