ESTRO 2025 - Abstract Book

S3966

Radiobiology - Tumour radiobiology

ESTRO 2025

Conclusion: The study demonstrated the predictive capability of DRM for treatment sensitivity in NPC. DRM IC created in the IC treatment provides the tumor spatial dose response to the CCRT treatment, which could not be replaced using a single image or pre-treatment parameters. These findings support the potential for integrating DRM into clinical practice to personalize radiotherapy plans and enhance therapeutic outcomes for NPC patients.

Keywords: nasopharyngeal carcinoma, DRM, TVCP

References: 1. Yan D, Chen S, Krauss DJ, Chen PY, Chinnaiyan P, Wilson GD. Tumor Voxel Dose-Response Matrix and Dose Prescription Function Derived Using (18)F-FDG PET/CT Images for Adaptive Dose Painting by Number. Int J Radiat Oncol Biol Phys . May 1 2019;104(1):207-218. doi:10.1016/j.ijrobp.2019.01.077 2.Yan D, Chen S, Krauss DJ, et al. Inter/intra-tumoral dose response variations assessed using FDG-PET/CT feedback images: Impact on tumor control and treatment dose prescription. Radiother Oncol . Jan 2021;154:235-242. doi:10.1016/j.radonc.2020.09.052

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Proffered Paper Evaluation of individualized targeted therapy combinations in lung cancer models using a heterogeneous cohort approach to minimize animal use Michael Ramirez Parra 1,2 , Nathalie Borgeaud 1,2 , Lydia Koi 3,2 , Claire Gordziel 3,2 , Soňa Michlíková 2 , Manuel Pfeifer 4 , Michael Baumann 5 , Steffen Löck 2,1,6 , Henning Willers 7 , Mechthild Krause 3,1,2 , Antje Dietrich 1,2 1 German Cancer Consortium (DKTK), Partner Site Dresden, German Cancer Research Center (DKFZ), Heidelberg, Germany. 2 OncoRay – National Center for Radiation Research in Oncology, Faculty of Medicine and University Hospital Carl Gustav Carus, TUD, TUD Dresden University of Technology, Helmholtz-Zentrum Dresden-Rossendorf, Dresden, Germany. 3 Department of Radiotherapy and Radiation Oncology, Faculty of Medicine and University Hospital Carl Gustav Carus, TUD, Dresden, Germany. 4 Institute of Legal Medicine, Faculty of Medicine and University Hospital Carl Gustav Carus, TUD, Dresden, Germany. 5 German Cancer Research Center (DKFZ), and German Cancer