ESTRO 2025 - Abstract Book

S3979

Radiobiology - Tumour radiobiology

ESTRO 2025

Figure 2. Changes in apoptosis-related protein expression in breast cancer models treated with GLP-1 RA and/or radiotherapy (*p<0.05; **p<0.01 vs. control).

Conclusion: This study demonstrates that combining GLP-1 receptor agonists with radiotherapy offers enhanced tumor control in a breast cancer model. The combined treatment significantly reduced tumor size, improved tissue morphology, and decreased angiogenesis markers such as VEGF-A and FGF-2. Additionally, the reduction in IL-6 and TNF-α levels indicates decreased inflammation, while moderated TGF-β expression suggests less extracellular matrix remodeling. Enhanced apoptotic activity, reflected by increased caspase-3 and caspase-7 levels, underscores the improved cancer cell death. These findings suggest that GLP-1 RAs, in combination with radiotherapy, may provide a promising therapeutic strategy, particularly for patients with diabetes and breast cancer, improving both treatment efficacy and reducing radiotherapy side effects.

Keywords: breast cancer, radiotherapy, breast cancer cells

1678

Mini-Oral MMP11 is a regulator of prostate cancer radioresistance and a promising liquid biopsy marker of prostate cancer progression Ielizaveta Gorodetska 1 , Vasyl Lukiyanchuk 2 , Marta Gawin 3 , Annett Linge 1,4,5 , Fabian Lohaus 4 , Tobias Hölscher 4 , Kati Erdmann 6 , Susanne Fuessel 6 , Angelika Borkowetz 6 , Mark Reardon 7 , Ananya Choudhury 7 , Yasmin Antonelli 8 , Aldo Leal-Egaña 8 , Ayse Sedef Köseer 2 , Uğur Kahya 2 , Jakob Püschel 1 , Daria Klusa 1 , Claudia Peitzsch 1 , Romy Kronstein Wiedemann 9 , Torsten Tonn 9 , Christian Thomas 6 , Piotr Widłak 3 , Monika Pietrowska 3 , Mechthild Krause 1,4,5 , Anna Dubrovska 1,2,5