ESTRO 2025 - Abstract Book

S3993

Radiobiology - Tumour radiobiology

ESTRO 2025

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Conclusion: Hypoxia-induced ECM remodelling is a prevalent pan-cancer process involving both HIF1/HIF2 dependent and independent regulation. Our signature predictive capacity should be evaluated beyond bladder cancer, as it was prognostic across several cancer types. Finally, our results suggest the signature’s predictive capacity associated with radiotherapy decreasing cell migration on hypoxic ECMs. This mechanism should be further validated and explored as it could identify novel therapeutic approaches in cancer.

Keywords: #pancancer #microenvironment #predictive_marker

References: 1. Muz, B. et al. Hypoxia 83 (2015).

2. Beckers et al. Seminars in Cancer Biology 98, 19-30 (2024) 3. Eke, I. et al. Radiotherapy and Oncology 99, 271–278 (2011). 4. Gilkes, D. M. et al. Nat Rev Cancer 14, 430–439 (2015).

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Mini-Oral Untargeted metabolomics reveals pyruvate kinase M (PKM) as potential radiosensitizer in triple-negative breast cancer cells Sandra Classen 1 , Rocio Matesanz-Sanchez 2 , Kanstantsin Siniuk 3 , Mirko Peitzsch 4 , Tiago Alves 5 , Helmut Pospiech 3,6,7 , Nils Cordes 2 , Kerstin Borgmann 1 1 Department of Radiotherapy & Radiation Oncology, Hubertus Wald Tumor Center - University Cancer Center Hamburg (UCCH), University Medical Center Hamburg-Eppendorf, Hamburg, Germany. 2 OncoRay - National Center for Radiation Research in Oncology, Faculty of Medicine and University Hospital Carl Gustav Carus, Technische Universität Dresden, Helmholtz-Zentrum Dresden-Rossendorf, Dresden, Germany. 3 Project Group Biochemistry, Leibniz Institute on Aging - Fritz Lipmann Institute, Jena, Germany. 4 Institute of Clinical Chemistry and Laboratory Medicine, University Hospital and Medical Faculty Carl Gustav Carus, Technische Universität, Dresden, Germany. 5 Institute for Medical Informatics and Biometry (IMB), Technische Universität Dresden, Dresden, Germany. 6 Faculty of Biochemistry and Molecular Medicine, University of Oulu, Oulu, Finland. 7 Research Laboratory of the Clinic for Gynecology and Obstetrics, University Hospital Düsseldorf, Düsseldorf, Germany