ESTRO 2025 - Abstract Book

S4021

Radiobiology - Tumour radiobiology

ESTRO 2025

Conclusion: The 55 gene hypoxia-associated signature for uterine cervical cancer was prognostic in two independent validation cohorts. The clinical utility of this biomarker and its influence on patient stratification may lead to better mechanistic understanding of the interplay between hypoxia and treatment.

Keywords: cervical cancer, hypoxia, gene expression

References: 1. Bray F, Laversanne M, Sung H, Ferlay J, Siegel RL, Soerjomataram I, Jemal A. Global cancer statistics 2022: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries. CA Cancer J Clin. 2024 May-Jun;74(3):229-263. doi: 10.3322/caac.21834. Epub 2024 Apr 4. PMID: 38572751. 2. Yang L, West CM. Hypoxia gene expression signatures as predictive biomarkers for personalising radiotherapy. Br J Radiol. 2019 Jan;92(1093):20180036. doi: 10.1259/bjr.20180036. Epub 2018 Mar 20. PMID: 29513038; PMCID: PMC6435086.

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Digital Poster In vitro study on the use of photosynthetic microalgae to radiosensitize hypoxic tumor cells Viviana Camacho, Karol Raccoursier, Hilde Harb Buzzá, Beatriz Sánchez-Nieto, Ignacio Espinoza Institute of Physics, Pontificia Universidad Católica de Chile, Santiago de Chile, Chile Purpose/Objective: Cellular hypoxia is a relevant cause of resistance in solid tumors treated with radiotherapy. To eliminate radioresistant cells, significantly higher radiation doses would be required, which is unfeasible due to the tolerance limits of healthy tissues near the tumor. A promising strategy to address this issue is the use of photosynthetic