ESTRO 2025 - Abstract Book

S428

Clinical - Breast

ESTRO 2025

Similarly, the mean doses received by the heart were significantly lower in the group that delineated the CA. ( p Mann Whitney U = 0.013) but V1,5Gy and V7 Gy are not significant different in this study ( p Mann-Whitney U = =0.063 , 0.163)

Also the homogeneity of the V 9Gy and D mean (Gy) of CA (measured using de standard deviations) are much better in patients with delineated CA (pF-Test<0.001 in both cases)

Conclusion: The delineation of the coronary arteries (CA) without imposing explicit dose constraints offers a valuable tool for incorporating dosimetric considerations into radiotherapy planning for left-sided breast cancer. By visualizing the CA within the treatment planning system, radiation oncologists can gain a better understanding of the potential impact of radiation on this critical structure. Although further research is necessary to definitively establish the clinical significance of CA delineation, the findings of this study suggest that this strategy may contribute to improved cardiac sparing during radiotherapy. By minimizing radiation exposure to the heart, it is anticipated that the risk of long-term cardiac complications, such as myocardial infarction and heart failure, may be reduced.

Keywords: Coronary Arteries, Breast Cancer, Radiotherapy

References: Taylor, Carolyn et al. “Cardiac Structure Injury After Radiotherapy for Breast Cancer: Cross-Sectional Study With