ESTRO 2025 - Abstract Book

S4390

RTT - Treatment planning, OAR and target definitions

ESTRO 2025

Conclusion: In our cohort of 10 EC-patients, using RAD instead of IMRT results in statistically significantly reduced dose to the lungs, which does not come at the expense of increased dose to the heart (moderately decreased) nor decreased target volume coverage (stable). The statistically significantly increased SpinalCordD 0.035cc is not clinically relevant. The decreased MLD results in a clinically meaningful reduction of the predicted PPC-risk. The ΔNTCP between IMRT and RAD in our analysis is of the same magnitude as that reported by Hoffmann et al. comparing photon versus proton therapy plans [2].

Keywords: esophageal cancer, toxicity, rapid arc dynamic

References: [1] Thomas M et al. NTCP model for postoperative complications and one-year mortality after trimodality treatment in oesophageal cancer. Radiother Oncol. (2019) [2] Hoffmann L et al. Treatment planning comparison in the PROTECT-trial randomising proton versus photon beam therapy in oesophageal cancer: Results from eight European centres. Radiother Oncol. (2022)

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Digital Poster CAN AUTOGENERATED TREATMENT PLANS REPLACE THOSE MADE MANUALLY BY TREATMENT PLANNERS? Malin Apelman 1,2 , Anna Bäck 2,3 , Thomas Henry 2,3 1 Institute of Health and Care Sciences,, University of Gothenburg, Gothenburg, Sweden. 2 Therapeutic Radiation Physics, Sahlgrenska University Hospital,, Gothenburg, Sweden. 3 Institute of Clinical Sciences, University of Gothenburg, Gothenburg, Sweden