ESTRO 2025 - Abstract Book

S4415

Late-breaking abstracts

ESTRO 2025

Conclusion This 10-year update confirms the previous findings of the HYPO-RT-PC trial: UHF is non-inferior to CF in terms of tumour control and has comparable late toxicity. Furthermore, the results suggest that the UHF schedule may offer greater efficiency than CF in the long term. These findings support UHF as a standard-of-care option for intermediate-risk prostate cancer.

Keywords: ultra-hypofractionation, prostate cancer

References [1] Widmark A, Gunnlaugsson A, Beckman L, Thellenberg-Karlsson C, Hoyer M, Lagerlund M, et al. Ultra hypofractionated versus conventionally fractionated radiotherapy for prostate cancer: 5-year outcomes of the HYPO-RT-PC randomised, non-inferiority, phase 3 trial. Lancet. 2019;394:385–95. https://doi.org/10.1016/S0140 6736(19)31131-6.

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Proffered Paper Hippocampal-avoidance whole-brain radiotherapy with dose escalation on metastases – Results of a prospective randomized trial (HIPPORAD) Anca L Grosu 1,2 , Claudia Schmoor 3 , Erika Graf 4 , Lars Frings 5 , Thomas Rothe 1 , Sabine Schneider-Fuchs 3 , Oliver Oehlke 6 , Ursula Nestle 1,6 , Florian Würschmidt 7 , Maximilian Niyazi 8,9 , Raphael Bodensohn 8,9 , Frank Paulsen 9 , Victor Lewitzki 10 , Jürgen Dunst 11 , Emmanouil Fokas 12 , Sophie Wetzel 13 , Ilja Ciernik 14 , Christian Dietzel 15 , Marcel Ott 16 , Linda Agolli 17 , Carsten Nieder 18,19 , Karl Egger 20 , Horst Urbach 20 , Claas Lahmann 21 , Ilinca Popp 1 1 Department of Radiation Oncology, Medical Center - University of Freiburg, Freiburg, Germany. 2 Partner Site Freiburg, German Cancer Consortium (DKTK), Freiburg, Germany. 3 Clinical Trials Unit, Medical Center - University of Freiburg, Freiburg, Germany. 4 Institute of Medical Biometry and Statistics, Medical Center - University of Freiburg, Freiburg, Germany. 5 Department of Nuclear Medicine, Medical Center - University of Freiburg, Freiburg, Germany. 6 Department of Radiation Oncology, Kliniken Maria Hilf GmbH, Mönchengladbach, Germany. 7 Department of Radiation Oncology, Radiologische Allianz, Hamburg, Germany. 8 Department of Radiation Oncology, University Hospital, LMU Munich, Munich, Germany. 9 Department of Radiation Oncology, University Hospital Tübingen, University of Tübingen, Tübingen, Germany. 10 Department of Radiation Oncology,