ESTRO 2025 - Abstract Book

S4429

Late-breaking abstracts

ESTRO 2025

Conclusion This study demonstrates that rapid-learning using real-world data can be used to quickly evaluate and refine a change in radiotherapy practice. Initial results suggest improved survival with CAA dose limitation in a representative lung cancer population. Ongoing analyses will assess the potential impact on longer-term survival, radiotherapy-related toxicities, and explore alternative modelling approaches to better understand treatment outcomes.

Keywords: Rapid-learning, lung cancer, cardiac toxicity

References 1

Banfill et al., J. Thorac. Oncol. , 2024 , doi:10.1016/j.jtocrr.2024.100742

2 McWilliam et al., Int. J. Radiat. Oncol. Biol. Phys. , 2020 , doi:10.1016/j.ijrobp.2020.06.031 3 Banfill et al., J. Thorac. Oncol. , 2021 , doi:10.1016/j.jtho.2020.11.002 4 Van Loon et al., Lancet Oncol. , 2012 , doi:10.1016/S1470-2045(11)70379-5 5 Price et al., Radiother. Oncol. , 2021 , doi:10.1016/j.radonc.2021.09.030 6 RAPID-RT Patient Advisory Group, https://www.youtube.com/watch?v=sTqXR4FqZ4g 7 Price et al., Clin. Oncol. , 2022 , doi:10.1016/j.clon.2021.12.017 8 Marchant et al., BJR|Open , 2023 , doi:10.1093/bjro/tzae006 9 Marchant et al., Radiother. Oncol. , 2025 , doi:10.1016/j.radonc.2024.110654 10 van Buuren et al., J. Stat. Softw. , 2011 , doi:10.18637/jss.v045.i03

5025

Proffered Paper Hypofractionated breast radiotherapy for 1 week vs 3 weeks: 10-year efficacy and late normal tissue effects in the FAST-Forward randomised trial Adrian M Brunt 1 , Fay Cafferty 2 , Duncan A Wheatley 3 , Jaymini Patel 2 , Mark A Sydenham 2 , Anna M Kirby 4 , Charlotte E Coles 5 , Karen Poole 2 , Helen Fleming 2 , Abdulla Alhasso 6 , David J Bloomfield 7 , Charlie Chan 8 , Mark Churn 9 , Susan Cleator 10 , Andrew Goodman 11 , Clare Griffin 2 , Joanne S Haviland 12 , Cliona C Kirwan 13 , Zohal Nabi 14 , Elinor Sawyer 15 , Navite Somaiah 16 , Isabel Syndikus 17 , John R Yarnold 18 , Judith M Bliss 2