ESTRO 2025 - Abstract Book

S456

Clinical - Breast

ESTRO 2025

Interestingly, among whole population experiencing OS event, 40.5% died from other causes than BC (including, 27% for other malignancies).

Conclusion: In one of the largest monocentric series collected to date, we confirmed how male BC represents a distinct clinical entity in which adjuvant RT seems to be safe and effective. Based on these outcomes, we could consider intensifying treatment for male BC patients, favoring towards RT even in borderline cases.Our findings support the need for more inclusive criteria in clinical trials of radiation therapy and the generation of high-quality, multicenter real-world data.

Keywords: male breast cancer, adjuvant radiotherapy

References: 1. A. Gucalp et al "Male breast cancer: a disease distinct from female breast cancer" Breast Cancer Res Treat. 2019 Jan;173(1):37-48. 2. RR Colciago et al "The role of radiation therapy in the multidisciplinary management of male breast cancer: a systematic review and meta-analysis" Crit Rev Oncol Hematol. 2024 Oct 23:104537

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Digital Poster Effect of preparatory coaching for Deep Inspiration Breath Hold on dosimetric parameters of heart and lung doses in adjuvant breast radiotherapy Laraib Khan 1 , Tooba Ali 1 , Maham Khan 1 , Fabiha Shakeel 1 , Aahan Arif 2 , Maria Tariq 1 , Asim Hafiz 1 , Ahmed Nadeem Abbasi 1 , Bilal Mazhar Qurehi 1 , Nasir Ali 1 1 Radiation Oncology, Aga Khan University Hospital, Karachi, Pakistan. 2 Medical College, Aga Khan University, Karachi, Pakistan Purpose/Objective: Radiation exposure to heart in women with left sided breast cancer can lead to cardiac disease related mortality 1 . Therefore, it is important to improve cardiac avoidance in patients undergoing radiotherapy for left sided breast cancer. For improving cardiac outcomes, several techniques have been used like deep inspiration breath hold (DIBH), respiratory gating, radiotherapy in prone position 2 . The aim of our study was to compare the maximum, mean and V5, V10, V30 Gy doses of heart and lung doses (V17 and V20) between coached and un coached patients using DIBH technique in left sided breast cancer radiotherapy. Material/Methods: Patients with left-sided breast cancer undergoing adjuvant radiotherapy, utilizing DIBH technique, were included in the study. This cohort was designated as uncoached patients. While these patients received verbal guidance regarding the breath hold technique, they did not undergo any formal coaching or structured training. In contrast, the second cohort involved the implementation of a comprehensive coaching protocol for the DIBH technique, which commenced in January and continued through June 2022. This protocol aimed to enhance the patients' understanding and execution of the breath hold technique to optimize cardiac protection during radiation therapy. Dosimetric parameters were analyzed using Dose Volume Histograms (DVH), which are part of the routine evaluation and approval process for radiation treatment plans.