ESTRO 2025 - Abstract Book

S490

Clinical - Breast

ESTRO 2025

highlighting a notable difference between the PBI and WBI groups.

Conclusion: This study shows that the use of adjuvant radiotherapy in early-stage breast cancer patients may approximately double the risk of developing lung cancer during the remaining lifetime in Korean patients. To decrease this risk, PBI should be preferred over WBI whenever clinically indicated. Also, the lowest possible dose should be used for both PBI and WBI, with planning focused on minimizing lung exposure.

Keywords: radiation induced lung cancer, radiation technique

References: 1. Grantzau T, Overgaard J. Risk of second non-breast cancer among patients treated with and without postoperative radiotherapy for primary breast cancer. Radiother Oncol 2016;121:402-13. 2. Taylor C, Correa C, Duane FK, Aznar MC, Anderson SJ, Bergh J, et al. Estimating the Risks of Breast Cancer Radiotherapy. J Clin Oncol 2017;35:1641-9. 3. Hoekstra N, Fleury E, Merino Lara TR, van der Baan P, et al. Long-term risks of secondary cancer for various whole and partial breast irradiation techniques. Radiother Oncol 2018;128:428-33. 4. Berrington de Gonzalez A, Iulian Apostoaei A, Veiga LH, Rajaraman P, Thomas BA, Owen Hoffman F, et al. RadRAT: a radiation risk assessment tool for lifetime cancer risk projection. J Radiol Prot 2012;32:205-22.

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Digital Poster Meta-Analysis of Randomized Controlled Trials Comparing Hypofractionated and Conventional Post Mastectomy Radiotherapy With or Without Reconstruction Bin Gui 1 , Meredith Akerman 2 , Yen-Ruh Wuu 1 , Plann-Curley Brendan 3 , Gabriella Wernicke 4 1 Radiation Medicine, Northwell, New Hyde Park, USA. 2 Biostatistics Unit Office of Academic Affairs, Northwell, New Hyde Park, USA. 3 Medical Library, Northwell, New York, USA. 4 Radiation Medicine, Northwell, New York, USA Purpose/Objective: Post-mastectomy radiation therapy (PMRT) has evolved to include conventional fractionation (CFPMRT), as well as the newer hypofractionated PMRT(HFPMRT) schedules with much support in the literature for the treatment