ESTRO 2025 - Abstract Book

S43

Invited Speaker

ESTRO 2025

available that may delay the appearance of BrM and secondary progression of previously treated BrM, there are still substantial unmet needs for this patient population and primary prevention remains elusive. Today many new agents are available to treat patients with brain metastases and HER2 positive disease. Antibody drug conjugates and tyrosine kinase inhibitors have demostrated benefit in mPFS and OS benefit. High response rates may permit, in some scenarios, to delay radiation therapy. During my talk I will address the treatment landscape of current available treatments

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Speaker Abstracts Commissioning of online adaptive RT system Alex Dunlop The Joint Department of Physics, The Institute of Cancer Research and The Royal Marsden Hospital, London, United Kingdom

Abstract:

In order to commission an online adaptive workflow, a risk assessment of all aspects of the treatment session, including which member of staff is performing what role, must be performed and checks should be implemented to ensure each of the steps are performed safely. This talk will focus on the solutions and mitigation strategies available for the additional challenges and risks associated with online adaptive radiotherapy (oART) that will be described in the first talk of this session. The risks associated with oART can be platform-specific and the talk will also explore additional risks that may be posed, and corresponding mitigation approaches, for workflows that use treatment planning software independent of the treatment platform.

4720 Speaker Abstracts Setting the scene: Challenges of online adaptive RT QA Sebastian Klüter Department of Radiation Oncology, University Hospital Heidelberg, Heidelberg, Germany Abstract

With online adaptive radiotherapy (OART) comes the need for new quality assurance methods. The most obvious difference is associated with the physical impossibility of plan verification measurements with the patient on the treatment couch. It is however not a given that this fact correlates with the greatest risks for patients in online adaptive workflows. In this talk, an overview over possible workflows for both CBCT- and MR-guided OART will be given. Looking at the problem from a risk-management perspective, particular risks associated with OART workflows and conceptional differences between OART QA and regular QA processes will be outlined. Additionally, the value of traditional QA metrics in the context of OART QA will be discussed.

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Speaker Abstracts Assessing health literacy in patients presenting for radiation therapy Toni Kelly 1 , Helen Warren-Forward 2 , Yolanda Surjan 2 , Marianne Rinks 3