ESTRO 2025 - Abstract Book

S500

Clinical - Breast

ESTRO 2025

Purpose/Objective: This meta-analysis evaluates the distinctions between Deep Inspiration Breath Hold (DIBH) and Free Breathing (FB) techniques in patients receiving postoperative radiotherapy for right-sided breast cancer, providing significant recommendations for clinical practice. Material/Methods: A systematic retrieval of controlled trials comparing DIBH and FB techniques in postoperative radiotherapy for right sided breast cancer was conducted utilizing the PubMed, Embase, Cochrane Library, and Web of Science databases. The primary outcomes assessed included the doses of adjacent normal tissues (heart, liver, and lungs). Summary standardized mean differences (SMD) along with 95% confidence intervals (CI) were computed, respectively. StataMP 17 software was selected to perform data analysis Results: he study encompassed an analysis of 313 patients derived from seven online studies, comprising 168 individuals in the DIBH group and 269 individuals in the FB group. The findings indicated that the DIBH group received significantly lower irradiation doses to the heart, liver, and lungs in comparison to the FB group, with statistical significance (heart dose: SMD = -0.63, 95% CI -0.85 to -0.41, P < 0.05; liver dose: SMD = -1.15, 95% CI -1.91 to -0.38, P < 0.05; lung dose: SMD = -0.79, 95% CI -1.23 to -0.35, P < 0.05). Conclusion: This meta-analysis indicated that the application of DIBH during postoperative radiotherapy for right-sided breast cancer markedly decreases radiation exposure to the heart, liver, and lungs, while maintaining consistent tumor dose coverage. References: 1.Sung H, Ferlay J, Siegel RL, Laversanne M, Soerjomataram I, Jemal A, Bray F: Global Cancer Statistics 2020: GLOBOCAN Estimates of Incidence and Mortality Worldwide for 36 Cancers in 185 Countries . CA Cancer J Clin 2021, 71 (3):209-249. 2.Zhang Y, Dong X, Guo X, Li C, Fan Y, Liu P, Yuan D, Ma X, Wang J, Zheng J et al : LncRNA-BC069792 suppresses tumor progression by targeting KCNQ4 in breast cancer . Mol Cancer 2023, 22 (1):41. 3.Lin L, Yan L, Liu Y, Yuan F, Li H, Ni J: Incidence and death in 29 cancer groups in 2017 and trend analysis from 1990 to 2017 from the Global Burden of Disease Study . J Hematol Oncol 2019, 12 (1):96. Keywords: Breast cancer,Deep inspiration breath hold Digital Poster LONG-TERM OUTCOMES OF VOLUME DE-ESCALATION FOR BREAST NODAL IRRADIATION Riccardo Ray Colciago 1 , Federica Ferrario 1,2 , Chiara Chissotti 1,2 , Giulia Rossano 1,2 , Lorenzo De Sanctis 1,2 , Valeria Faccenda 3 , Denis Panizza 3 , Sara Trivellato 3 , Stefano Arcangeli 1,2 1 Medicine and Surgery Department, University of Milan Bicocca, Milan, Italy. 2 Radiation Oncology Unity, Fondazione IRCCS San Gerardo dei Tintori, Monza, Italy. 3 Medical Physiscs Unit, Fondazione IRCCS San Gerardo dei Tintori, Monza, Italy Purpose/Objective: NCCN recommendations suggest irradiating only untreated axillary levels for node-positive breast cancer (BC) patients. We analyzed a cohort of node-positive BC patients who received adjuvant radiotherapy (RT) with a volume de-escalation at the level of axillary nodes. 1895