ESTRO 2025 - Abstract Book

S535

Clinical - Breast

ESTRO 2025

Results: A total of 101 BC women were included. CAC score progression occurred in 28 BC patients (27.7% of the cohort). A sustained elevation in CRP levels was significantly associated with the increased risk of early CAC score progression (adjusted OR = 3.08 [1.07-8.84], p-value = 0.04). No significant association was observed for other inflammatory biomarkers. A higher radiation dose to the left ventricle was also associated with the increased risk of early CAC score progression (adjusted OR = 1.15 [1.00-1.62], p-value = 0.04). The combined model of sustained c-reactive protein elevation and left ventricle radiation dose had the best predictive power of the risk of early CAC score progression (AUC = 0.733 [0.616-0.850]). Conclusion: Sustained inflammation, indicated by sustained elevations of CRP levels, was a significant predictor of early CAC score progression in BC patients after RT. These findings suggest that inflammation could play a key role in radiation-induced cardiovascular risk, including the risk of atherosclerosis, underscoring the importance of monitoring inflammation in BC patients undergoing RT

Keywords: inflammation; biomarker; CAC

2532

Digital Poster RAD-EMPATH: Early Radiation Oncology review at breast cancer diagnosis before primary systemic therapy to empower patients & healthcare professionals Kathryn Haley 1,2 , Sinead Horan 2 , John Jones 2 , Luca Burchini 2 , Gemma Farmer 2 , Joseph Martin 1 , Jill Nicholson 2,3 , Orla McKenna 2,4 , Sara Faithfull 3,5 , Nicola Elmer 2 , Michelle Leech 3 , Frances K Duane 2,3,4 1 Radiation Oncology, University Hospital Galway, Galway, Ireland. 2 Radiation Oncology, St Luke's Radiation Oncology Network, Dublin, Ireland. 3 Discipline of Radiation Therapy, Trinity College Dublin, Dublin, Ireland. 4 Trinity St James Cancer Institute, Trinity College Dublin, Dublin, Ireland. 5 School of Health Sciences, University of Surrey, Surrey, United Kingdom Purpose/Objective: A multidisciplinary care team (MDT) agrees on individualised management plans for patients with breast cancer. Radiation oncology input may be enhanced by offering early review for patients at diagnosis prior to commencement of primary systemic therapy (PST). Early radiation oncology review offers the opportunity for clinical assessment and examination, screening for clinical research study eligibility, advice on the likelihood of post operative radiotherapy and the pros and cons of various loco-regional therapy approaches, and informs patients of an agenda which facilitates advance personal life planning (Figure 1). This study explores patient perspectives of such an approach.