ESTRO 2025 - Abstract Book

S564

Clinical - Breast

ESTRO 2025

Median Age: 52y (31–89), Median Weight at Study Start and End: 68kg (45–104), Breast Affected right/left (16/24), Surgery Type BCS/SSM (29/11) , Tumor Subtypes Luminal/HER2+/TNBC (27/5/8) , PTV Median Volume: 1,450 cc (575– 1,450cc) , Radiation Techniques 3D-CRT/VMAT (7/33), Median Breast Volume at Day 1 386cc (98 cc–1243 cc.). Breast volume changes over time are shown in Figure 2. Volumes slightly decreased from Scan 1 to Scan 2 (∆-7,3 cc), increased from Scan 2 to Scan 3 (∆5,9 cc), and from Scan 3 to Scan 4 (∆32,9 cc), and then decreased from Scan 4 to Scan 5 (∆-10,9cc), Non-Radiated Breast presented no significant changes. BCS patients showed significantly smaller changes in volume compared to SSM patients with implant reconstruction. The relationship between weight, capsular fibrosis and volume changes is under investigation. PROMS analysis is also ongoing

Conclusion: The 3DSI method showed a trend to long-term volume reduction in the radiated breasts. This trend was particularly strong in SSM patients with implant reconstruction, beyond just weight loss. This information may help in determining the optimal implant size at time of surgery and objectively inform patients.

Keywords: breast surface imaging, cosmetic outcomes

References: Koban KC, Etzel L, Li Z, Pazos M, Schönecker S, Belka C, Giunta RE, Schenck TL, Corradini S. Three-dimensional surface imaging in breast cancer: a new tool for clinical studies? Radiat Oncol. 2020 Feb 28;15(1):52. doi: 10.1186/s13014-020-01499-2. PMID: 32111228; PMCID: PMC7049187.