ESTRO 2025 - Abstract Book

S572

Clinical - Breast

ESTRO 2025

Of the patients who completed all the questionnaires, the most frequent symptoms at the start of RT were asthenia, dryness, pruritus, altered skin pigmentation and hypersensitivity (all mild-moderate and one case of severe asthenia). During treatment, an increase in the frequency and intensity of all symptoms was observed, with mastalgia and asthenia standing out, both with one case reported as intense. At the end of RT, all symptoms increased in frequency, with asthenia, dryness, hypersensitivity and pruritus being more intense. One month after RT, most symptoms improved, although the frequency remained higher than at the beginning of RT, with asthenia, pruritus, hypersensitivity and hyperpigmentation (all of them of mild-moderate intensity) being the most pronounced.

All the patients who completed the PREMS questionnaire, one month after RT, rated the treatment received as excellent, highlighting the transmission of information and the attention received in all sections of the department.

Conclusion: The use of PROMS-PREMS allows us to know the patients' experience during treatment and helps us to offer them the best possible care.

Keywords: Life Quality, Questionnaires

3337

Proffered Paper Beyond the First Cut: A Comparison of Breast Induration in Breast Cancer Patients With and Without Repeat Surgery Based on DBCG Data Kristine Wiborg Høgsbjerg 1 , Else Maae 2 , Mette Holck Nielsen 3 , Lars Eric Stenbygaard 4 , Maja Vestmø Maraldo 5 , Mette Skovhus Thomsen 6 , Peer Michael Christiansen 7 , Jens Overgaard 1 , Birgitte Vrou Offersen 1 1 Department of Experimental Clinical Oncology, Aarhus University Hospital, Aarhus, Denmark. 2 Department of Oncology, Vejle Hospital, University of Southern Denmark, Vejle, Denmark. 3 Department of Oncology, Odense University Hospital, Odense, Denmark. 4 Department of Oncology, Aalborg University Hospital, Aalborg, Denmark. 5 Department of Oncology, Copenhagen University Hospital, Rigshospitalet, Copenhagen, Denmark. 6 Department of Medical Physics, Aarhus University Hospital, Aarhus, Denmark. 7 Department of Plastic- and Breast Surgery, Aarhus University Hospital, Aarhus, Denmark Purpose/Objective: Breast-conserving surgery followed by whole breast irradiation (WBI) is standard for most breast cancer patients. For patients with node-negative breast cancer long-term survival, optimising treatment while minimising late effects is essential [1-3]. Repeat surgery, often required due to incomplete margins, may increase late effects. This study aimed to evaluate late effects in contemporarily treated patients undergoing repeat surgery. Material/Methods: Patients receiving WBI were included from the two randomised phase III trials, DBCG HYPO (2009-2014) and PBI (2009-2016) [2, 3] and categorised based on repeat surgery (RS) yes/no performed within 60 days. The primary endpoint in DBCG HYPO and PBI trials was the 3-year grade 2–3 breast induration rate. Evaluations were conducted annually from 1 to 5 years and at 10 years of follow-up. This study reports the cumulative incidence of grade 2–3 induration at 3 and 5 years, calculated using the Aalen-Johansen estimator with competing risk analysis. The cumulative incidence of induration was assessed starting from year two to disregard initial surgical healing. Results: A total of 1,952 patients were included, with 312 undergoing RS and 1,640 not (NoRS). The median age was 63.6 years, with 62.7 years in the RS group and 63.8 years in the NoRS group. Overall, 197 had ductal carcinoma in situ (DCIS) and 1,755 had invasive cancer. DCIS was more common in the RS group (19%) compared to the NoRS group