ESTRO 2025 - Abstract Book

S588

Clinical - Breast

ESTRO 2025

From February 2024 to November 2024 a total of 243 patients have answered the survey (Denmark n=120, Germany n=0, Italy n=38, the Netherlands n=6, Portugal n=39, and Slovenia n=40). Median age was 60 years (range: 28-89), 15.6% (CI95% 11.3-20.8) were active smokers. Most patients had positive attitudes towards a risk prediction, 88.1% (CI95% 83.3-91.9), 88.9% (CI95% 84.3-92.6), 87.2% (CI95% 82.4-91.2), and 86.4% (CI95% 81.5-90.5) for CVD, OP, COPD, and UFB, respectively. Notably, lower positive attitude was observed in Italy, with 68.4% (CI95% 52.5-80.1), 68.4% (CI95% 52.5-80.1), 68.4% (CI95% 52.5-80.1), and 63.2% (CI95% 47.3-76.6) for CVD, OP, COPD, and UFB, respectively, compared to the other countries. For all responders, there was a weak but significant correlation between increasing age and a non-positive attitude towards AI-generated risk prediction (r=0.252, p=<0.001). Conclusion: In an unselected cohort of early breast cancer referred for postoperative RT, we found a highly positive attitude towards the use of an AI-generated risk prediction of developing common chronic diseases. References: 1) Global Cancer Observatory, WHO. www.gco.iarc.who.int 2) F Lundberg et al. Trends in cancer survival in the Nordic Countries 1990-2016: the NORCAN survival studies. Acta Oncology. Nov 2020. 3) European Breast Cancer Coalition. www.europadonna.org. 4) H Ng et al. Patterns of comorbidities in women with breast cancer: a Canadian population-based study. Cancer Causes & Control. Jul 2019. 5) D Rey et al. Evolution of physical activity and body weight gain changes in breast cancer survivors five years after diagnosis. Breast. Oct 2021. 6) CW Taylor et al. Cardiac Side-effects from Breast Cancer Radiotherapy. Clinical Oncology. Nov 2015. 7) National Cancer Institute. Cancer Trends Report. 2023. 8) ARTILLERY Project. www.artillery-project.eu. Keywords: Early breast cancer, AI, non-communicable disease Digital Poster Hyaluronic acid cream to prevent radiodermatitis in breast cancer patients treated with postoperative RT: A mono-centre, prospective, randomized trial Letizia Deantonio 1,2 , Giulia Borgonovo 1 , MariaAntonietta Piliero 3 , Andrea Puliatti 1 , Paola Canino 1 , Thomas Zilli 1,2 , Maria Carla Valli 1 , Antonella Richetti 1 1 Radiotherapy, IOSI, Bellinzona, Switzerland. 2 Faculty of Biomedical Sciences, Università della Svizzera Italiana, Lugano, Switzerland. 3 Medical Physics, IMSI, Bellinzona, Switzerland Purpose/Objective: This prospective randomized double-blind study aims to investigate the efficacy of a hyaluronic acid (HA) 0.2% cream in reducing the development of grade 2 or higher radiation dermatitis during adjuvant breast radiotherapy (RT) compared to a neutral comparator cream. Material/Methods: We enrolled women with breast cancer (stage I-III) candidates to adjuvant breast RT either with conventional fractionation (50 Gy, 2 Gy/fr + tumour bed boost of 10 Gy 2 Gy/fr ) or hypofractionation (40 Gy 2.667 Gy/fr). Patients were randomly assigned to apply either HA cream or the neutral comparator (placebo) twice daily, starting two weeks before beginning RT, and continuing during, until two weeks after the last fraction of RT. Weekly radiodermatitis was graded by the physicians using the RTOG scale. Skin changes were also assessed with weekly skin reflectance spectrophotometry (SRS). 3609