ESTRO 2025 - Abstract Book

S628

Clinical - Breast

ESTRO 2025

Results: A total of 775 patients were included with a mean follow-up of 4.5 years. Compared to patients with moderate/severe fibrosis, patients with none/mild fibrosis reported a statistically significant and clinically relevant better QoL on all domains of the three questionnaires, except for Sexual functioning and Sexual enjoyment of EORTC QLQ-BR23 and Physical as well as Social functioning domains of EORTC QLQ-C30 (Table 1). Patients with excellent/good cosmetic outcome reported a statistically significant and clinically relevant better QoL than patients with fair/poor cosmetic outcome on five out of 18 QoL domains (i.e., Sexual well-being, Psychosocial well-being and Satisfaction with breasts domain of Breast-Q and Body image and Sexual enjoyment domain of EORTC QLQ-BR23), but not on any of the Symptoms domains (Table 1).

Conclusion: Our study emphasizes that fibrosis and unfavorable cosmetic outcome are negatively associated with various QoL domains. In addition, fibrosis is associated with local symptoms, pain and fatigue, whereas unfavorable cosmetic outcome is not. This large multicenter study corroborates the interrelated nature of fibrosis and cosmetic outcome, although this is not a one-to-one relationship. A dual focus on preventing fibrosis and ensuring good cosmetic results is essential to optimize QoL after BCT.

Keywords: fibrosis, cosmetic outcome, quality of life

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