ESTRO 2025 - Abstract Book

S689

Clinical - CNS

ESTRO 2025

Conclusion: We identified a representative pattern for RICE occurrence: RICE was more likely to occur for eccentrically located tumors along the CTV borders within LET d elevated areas, close to ventricles, and in the regions receiving approximately prescribed doses, termed eccentrical BLVD. This finding can be used for RICE awareness and providing direction for treatment planning.

Keywords: brain, patient outcome, LET

2032

Mini-Oral Dose-response modelling of stereotactic radiosurgery for brain metastases: preliminary prospective data from the SAFER study (IRAS 276567) James de Boisanger 1,2 , Jessica Konadu 1 , Julia Henderson 1 , Philip Benjamin 1 , Amina Tran 3 , Sabine Dreibe 4 , Karen Thomas 3 , Emma Harris 5 , Martin Brewer 1 , Francesca Solda 1 , Antonia Creak 1 , Liam Welsh 1 , Nicola Rosenfelder 1,2 1 Neuro-oncology, The Royal Marsden Hospital, London, United Kingdom. 2 Neuro-oncology, The Institute of Cancer Research, London, United Kingdom. 3 Statistics, The Royal Marsden Hospital, London, United Kingdom. 4 Statistics, The Institute of Cancer Research, London, United Kingdom. 5 Imaging, The Institute of Cancer Research, London, United Kingdom