ESTRO 2025 - Abstract Book

S696

Clinical - CNS

ESTRO 2025

Results: On univariable LMM, Conformal radiotherapy resulted in significant improvements in neurocognitive domains over time, including HVLT-Immediate Recall (Estimate = 0.484, SE = 0.090, p < 0.001), HVLT-Delayed Recall (Estimate = 0.261, SE = 0.053, p < 0.001), and HVLT-Retention (Estimate = 1.827, SE = 0.585, p = 0.003). Similarly, QoL improvement was notable in the headache domain (Estimate = −6.268, SE = 2.130, p = 0.005) over the 6-month follow-up period. Multivariable LMM identified age, gender, and KPS as significant factors influencing NCF improvement, including MMSE and HVLT-Delayed Recognition (Figure.1a). For QoL, gender, KPS, and symptomatic brain metastases (BM) were identified as significant factors(Figure.1b).

Figure.1

The median IC-PFS was 30.5 months (95% CI: 27.5-33.5 months) for the overall cohort, with no significant difference between the SRT and HA-WBRT+SIB groups (Figure 2a). The survival data analysis showed that patients who received repeat cranial radiotherapy after intracranial progression had improved outcomes compared to those who were ineligible for repeat treatment (Figure.2b).