ESTRO 2025 - Abstract Book

S708

Clinical - CNS

ESTRO 2025

Conclusion: In patients receiving single fraction SRS to SBM, the locoregional at-risk normal brain V 15 Gy was the best dosimetric predictor of symptomatic RN. During plan optimization, a V 15Gy < 5 cc and a V 18Gy < 4 cc were associated with a symptomatic RN risk of 5% in the modern era.

Keywords: SRS, Brain metastases, Radiation necrosis

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Digital Poster Does retinoic acid-induced growth-response influence the outcome of irradiation in glioblastoma cells? Ana Ciocan 1 , Collette Hand 2 , Andrew England 1 , Annemarie Devine 1 , Theresa O' Donovan 1 , Mark Mc Entee 1 , Paul Kelly 3 , Erica Bennett 3 , Karen Molan 3 , Kieran Condon 3 , Eoin Toomey 3 , Tom Huxford 3 , Andre Toulouse 4 1 Discipline of Medical Imaging and Radiation Therapy, School of Medicine, University College Cork, Cork, Ireland. 2 Department of Pathology, School of Medicine, University College Cork, Cork, Ireland. 3 Bon Secours Radiotherapy in Partnership with UPMC Hillman Cancer Centre, Bons Secours Hospital, Cork, Ireland. 4 Department of anatomy and neuroscience, School of Medicine, University College Cork, Cork, Ireland