ESTRO 2025 - Abstract Book

S715

Clinical - CNS

ESTRO 2025

OEF maps demonstrated an AUC of 0.63 with a specificity and sensitivity of 0.722 and 0.462. Both the CTH and OEF biomarkers individually outperformed conventional rCBV maps in identifying active disease within FLAIR hyperintensity (Figure 2).

The analysis involved a voxel-based comparison of recurrence volume in the pre-RT imaging.

Conclusion: CTH and OEF maps show strong predictive capabilities for recurrence, capturing vascular characteristics and oxygenation levels not detected by standard MRI. Their integration into clinical workflows could enhance RT targeting, also in distinguishing active disease within FLAIR hyperintensity and provide essential information with minimal additional time, supporting personalized treatment strategies.

Keywords: Glioma,Perfusion Biomarkers,Recurrence Prediction

References: 1. Park JE, at al. Prediction of pseudoprogression in post-treatment glioblastoma using dynamic susceptibility contrast-derived oxygenation and microvascular transit time heterogeneity measures. Eur Radiol. 2024 May; doi: 10.1007/s00330-023-10324-9.