ESTRO 2025 - Abstract Book

S805

Clinical - Gynaecology

ESTRO 2025

Conclusion: This analysis provided NTCP models for late GI toxicity. EBRT technique plays a major role for late ≥G2 GI toxicity. BB and TB parameters and surgical characteristics mostly contribute to persistent GI toxicity. The NTCP model for persistent toxicity can support IMRT optimization and assist prospective patient selection for future trials testing advanced radiotherapy techniques (e.g proton therapy) for postoperative cervical cancer.

Keywords: NTCP, gastrointestinal toxicity, bowel dose

References: 1. Chopra S et al. Late toxicity after adjuvant conventional radiation versus image-guided intensity-modulated radiotherapy for cervical cancer (PARCER): a randomized controlled trial. Journal of Clinical Oncology. 2021;39:3682 92. 2. Ranjan N et al. Months and Severity Score (MOSES) in a Phase III trial (PARCER): A new comprehensive method for reporting adverse events in oncology clinical trials. EClinicalMedicine. 2022;47. 3. Gay HA et al. Pelvic Normal Tissue Contouring Guidelines for Radiation Therapy: A Radiation Therapy Oncology Group Consensus Panel Atlas. International Journal of Radiation Oncology*Biology*Physics. 2012;83(3):e353-e62.

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Poster Discussion Exploring Adjuvant Treatment Practices in Vulvar Cancer Radiotherapy: Insights from an International Survey Gabriella Macchia 1 , Alina Emiliana Sturdza 2 , Valentina Lancellotta 3 , Simona Maria Fragomeni 4 , Alexandra Taylor 5 , Carien L. Creutzberg 6 , Maaike Oonk 7 , Daniela Fischerová 8 , Donato Pezzulla 1 , Francesco Deodato 1,9 , Giovanni Scambia 4 , Maria Antonietta Gambacorta 3,9 , Giorgia Garganese 4 , Luca Tagliaferri 3