ESTRO 2025 - Abstract Book

S822

Clinical - Gynaecology

ESTRO 2025

Conclusion: Adjuvant SPIR for early-stage cervical cancer patients with IR factors provides excellent LC and PC after a long follow-up duration compared to WPIR, highlighting no need for wide pelvic irradiation.

Keywords: cervical cancer, adjuvant RT, small pelvis RT

2224

Digital Poster Quality of life and sexual health in endometrial carcinoma patients treated with adjuvant radiotherapy Arancha Gallego Barranco, Sofía Córdoba Largo, Beatriz Gil Haro, Francisco Javier Martínez Paredes, Cristina De la Fuente Alonso, Sofía Santana Jimenez, Sara Pérez Mata, Joaquín Velasco Jimenez, Marta López Valcarcel, Raquel Benlloch Rodriguez, María Hernández Miguel, Irma Zapata Paz, Maria Isabel García Berrocal, Carlota Cascajares Sanz, Mariela Rojas Quesada, Susana Sánchez Rico, Jose Cantillana Barrenas, Sofía Merino Pedraza, Clara Caballero Valls, Irene Ávila Gómez, Peppa Abelairas, Jesús Romero Fernández Radiation Oncology, Hospital Universitario Puerta de Hierro Majadahonda, Madrid, Spain Purpose/Objective: To evaluate clinical outcomes, quality of life (QoL) and sexual health (SH) in patients treated with adjuvant radiotherapy for endometrial carcinoma (EC). Material/Methods: Between 2020-2023, 74 patients (p) with stages I-IV EC were treated with adjuvant RT in our department (TNM staging: I: 42p, II: 15p, III/IV: 17p). Mean age: 67 years (44-88). All patients were treated with external beam radiotherapy (EBRT), brachytherapy (IGBT), or a combination of both, using 3D-based planning for intracavitary/interstitial IGBT following GEC-ESTRO recommendations, (Figure-1). Pathologic stage, grading, and molecular diagnosis were analyzed for their impact on locoregional relapse, metastases, and tumor-related death. Toxicity, QoL, and SH were evaluated in 31p using CTCAE v.5.0. EORTC QLQ-C30, QLQ-EN24 (EC-specific), and QLQ SH22. Additionally Spanish version of FSFI-questionnaire was used to evaluate female sexual-function, and validated Spanish FSM2-questionnaire, which cannot diagnose sexual dysfunction but allows comparison of SH between individuals or groups. Statistical analysis: Kaplan-Meier method, Logrank test and Chi-square test.