ESTRO 2025 - Abstract Book

S845

Clinical - Gynaecology

ESTRO 2025

2921

Poster Discussion Clinical Outcomes in Endometrial Cancer Patients Over 80 Years Old: A Multicenter Retrospective Study of Surgery with and without Radiotherapy Javier Anchuelo 1 , Pedro Muñoz 2 , Arantxa Campos 1 , Belén De Paula 3 , José Domínguez 4 , Piedad Galdós 5 , Elena García 6 , Sonia García 7 , Elisabeth González 8 , Teresa Muñoz 9 , Dina Najjari 10 , Paola Navarrete 5 , Dolores Peña 11 , Pedro Prada 5 , Ana L Rivero 5 , Andrea Slocker 10 , Pilar Samper 11 , María del Carmen Salas 12 , Jesús Mazaira 13 , Ana de Juan 14 , Rosa Mora 15 , Ángels Rovirosa 16 1 Radiation Oncology, Hospital Universitario Miguel Servet, Zaragoza, Spain. 2 Gerencia de Atención Primaria, Servicio Cántabro de Salud, Santander, Spain. 3 Radiation Oncology, Onkologikoa, Donosti, Spain. 4 Radiation Oncology, Hospital Ramón y Cajal, Madrid, Spain. 5 Radiation Oncology, Hospital Universitario Marqués de Valdecilla, Santander, Spain. 6 Radiation Oncology, Hospital Universitario Nuestra Señora de Candelaria, Tenerife, Spain. 7 Radiation Oncology, Hospital Universitario Reina Sofia, Córdoba, Spain. 8 Radiation Oncology, Hospital Universitario La Paz, Madrid, Spain. 9 Radiation Oncology, Hospital Ramón y Cajal, Madrid, Spain. 10 Radiation Oncology, Instituto Catalan de Oncología, Bellvitge, Spain. 11 Radiation Oncology, Hospital Universitario Rey Juan Carlos, Móstoles, Spain. 12 Radiation Oncology, Hospital Universitario Puerta del Mar, Cádiz, Spain. 13 Gynaecology, Hospital General Sierrallana, Torrelavega, Spain. 14 Medical Oncology, Hospital Universitario Marqués de Valdecilla, Santander, Spain. 15 Gynaecology, Hospital Universitario Marqués de Valdecilla, Santander, Spain. 16 Radiation Oncology, Hospital Clinic, Barcelona, Spain Purpose/Objective: The management of elderly patients with endometrial cancer is challenging due to comorbidities and age-related factors. This study aimed to evaluate clinical outcomes, survival, and toxicity profiles in endometrial cancer patients aged over 80 years treated with postoperative radiotherapy across multiple Spanish hospitals. Material/Methods: This retrospective study included 353 patients aged ≥80 years diagnosed with endometrial cancer and surgically treated between 2003 and 2019 across 19 Spanish hospitals. Adjuvant radiotherapy (external beam radiotherapy [EBRT] and/or brachytherapy) was delivered based on clinical risk factors. Outcomes assessed included local control, disease-free survival (DFS), cancer-specific survival (CSS), and overall survival (OS) at 1, 2, and 5 years. Chronic gastrointestinal and genitourinary toxicity was recorded. Kaplan-Meier survival analyses and Cox proportional hazards models identified prognostic factors.