ESTRO 2025 - Abstract Book

S848

Clinical - Gynaecology

ESTRO 2025

Results: The median follow up was of 10 months (1-30). From all the 18 lesions 11 had a complete response (61,1%), 5 had a partial response (27,8%) and 2 had clinical stability (11,1%). Fourteen of them progressed: 4 as nodal metastasis (22.2%), 6 as visceral metastasis (33.3%), and 4 as both (22.2%). There was no relapse in the irradiation field, achieving a local control rate of 100%. One year overall survival was 88.9%. The disease free survival was 3 months (1-12). The systemic free interval was of 7.5 months (2-13). Conclusion: SBRT has become an active treatment for ovarian cancer, effectively controlling oligometastatic disease and delaying the need for additional treatment/ new treatment. However, the high progression rate outside the irradiation field highlights the need for further research on the role of SBRT in combination with new drugs.

Keywords: Ovarian, SBRT

References: Chalkidou, (2020). t. Slevin F. Radiother Oncol. 2021 Macchia G. Clin Oncol (R Coll Radiol). 2023 Oct. Reshko et al, 2020 Barcellini A et al Life Basel. 2022. Bi Y, Gynecol Oncol. 2018 Lazzari R et . Int J Radiat Oncol Biol Phys. 2018 Macchia G. Oncologist. 2020; Macchia G, Int J Gynecol Cancer. 2022 Nero C et al Cancers (Basel). 2021 Leung et al. Radiat Oncol. 2020 Jan 30;15(1)

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Poster Discussion Pelvic insufficiency fractures (PIF) in cervical cancer patients treated with definitive chemoradiation: impact of dosimetric and clinical factors Rosa Autorino 1 , Raffaella Michela Rinaldi 1 , Davide Cusumano 2 , Roberta Giannini 1 , Viola De Luca 1 , Maura Campitelli 1 , Valentina Lancellotta 1 , Gabriella Macchia 3 , Nicolò Bizzarri 4 , Maria Gabriella Ferrandina 4 , Maria Antonietta Gambacorta 1 1 1. Department of Radiation Oncology, Fondazione Policlinico Universitario A. Gemelli IRCCS, Rome, Italy. 2 2. UO Fisica Medica e Radioprotezione, Mater Olbia, Olbia, Italy. 3 3. UOC Radiation Oncology Unit, Responsible Research Hospital, Campobasso, Italy. 4 4. Department of Women and Child’s Health Sciences and Public Health, Fondazione Policlinico Universitario A. Gemelli IRCCS, Rome, Italy Purpose/Objective: To investigate the correlation between clinical and dosimetric factors with the incidence of pelvic insufficiency fractures in patients affected by cervical cancer treated with radical radiotherapy in association or not with chemotherapy and to find possible dose constraints useful for reducing the risk. Material/Methods: We reviewed data from cervical cancer patients treated with pelvic external-beam RT in our Institution between 2020 and 2023. For each patient, pelvic bone marrow (BM) was contoured and divided into three subsites: lumbosacral spine (LSBM), ilium (IBM) and lower pelvis (LPBM). Data on the volume of each region receiving 10, 20,