ESTRO 2025 - Abstract Book

S878

Clinical - Gynaecology

ESTRO 2025

Keywords: GYN tumours, brachytherapy, EBRT boost,

References: 1. Tanderup K, et al. Curative radiation therapy for locally advanced cervical cancer: brachytherapy is NOT optional Int J Radiat Oncol Biol Phys 2014 Mar 1;88(3):537-9. 2. Sturdza A, et al. Image guided brachytherapy in locally advanced cervical cancer: Improved pelvic control and survival in RetroEMBRACE, a multicenter cohort study. Radiother Oncol 2016; 120: 428–33. 3. Cibula D, et al. ESGO/ESTRO/ESP Guidelines for the management of patients with cervical cancer - Update 2023. Radiother Oncol. 2023 Jul; 184:109682. 4. Potter R, et al. MRI-guided adaptive brachytherapy in locally advanced cervical cancer (EMBRACE-I): a multicentre prospective cohort study. Lancet Oncol 2021 Apr;22(4):538-547. Int J Gynecol Cancer

4267

Digital Poster Impact of Bone Marrow Dose from Chemoradiation on Acute Hematologic Toxicities in Locally Advanced Cervical Cancer with VMAT Technique Ambedkar Yadala, Ramkumar R, Ebenezer Staines, Pradeep S, Midhul M Joseph, Bhargav Shreeram Gundapuneedi, Shyama Sudha Prem, Parameshwari R, Kalaranjani M, Pooja Sethi Radiation Oncology, Jawaharlal Institute of Postgraduate Medical Education and Research, Puducherry, India Purpose/Objective: Chemoradiation is the standard treatment for locally advanced cervical cancer (Stages IB2 to IVA)(1), but acute haematological toxicities remain a significant challenge. These toxicities, such as anaemia, neutropenia, and thrombocytopenia, can lead to treatment interruptions, which extend overall treatment time and adversely affect survival outcomes. Chemotherapy and incidental radiation dose deposition in the pelvic and lumbar bones