ESTRO 2025 - Abstract Book

S882

Clinical - Gynaecology

ESTRO 2025

4359

Digital Poster Vaginal Stenosis as a Complication of Radiation Therapy in Cervical Cancer: Incidence and Predictive Factors – A retrospective study of 250 patients ikram el ochi Radiotherapy-Brachytherapy, Oncology Hospital, FES, Morocco

Purpose/Objective: This study aimed to assess the incidence and risk factors of radiation-induced VS in patients with cervical cancer .

Material/Methods: We retrospectively identified 230 patients with locally advanced cervical cancer treated with definitive radiotherapy (RT) and followed up at our institution. Results: A total of 230 patients were included in the study. Among them, 78% were under 60 years old and 22% were over 60, with an overall mean age of 49 years. Staging at diagnosis was as follows: 5% of patients at stage IB, 53% at stage II, 37% at stage III, and 5.5% at stage IV. Regarding marital status, 69% were married, 26% divorced, and 4% widowed at the time of diagnosis. With respect to vaginal involvement, 13.3% had no vaginal involvement, 69.3% had involvement in the middle third, and 17.3% in the upper third of the vagina. Late VS occurred in 28% of patients with grade 1 toxicity (partial stenosis) and 11% with grade 2 toxicity (complete occlusion). The mean time to the onset of stenosis was six months after the completion of treatment. Key prognostic factors associated with an increased risk of stenosis included age over 50 and being unmarried. Conclusion: The high incidence of late VS highlights the importance of early identification and targeted interventions to prevent its development. Advanced age and marital status were identified as significant predictive factors, emphasizing the need for proactive management strategies in at-risk patients. Digital Poster Treatment Outcomes and Survival Analysis of Cervical Cancer Patients at a Tertiary Oncology Center in Uganda Solomon Kibudde 1,2 , Daniel Mukasa Kanyike 1 , Israel Luutu 1 , Madelyn Fahhoum 3 , Sara Beltran Ponce 3 , John Bosco Ndinawe 4 , Kelvin Roland Mubiru 5 , Victoria Nankabirwa 6 , Miriam Nakalembe 7 , Bonny Abal 1 , Awusi Kavuma 1 , Pauline Byakika-Kwibika 8 , Warren Phipps 9,5 , Jackson Orem 10 , Pius Mulamira 11 , Nixon Niyonzima 12 , Kirsten Beyer 13 , Jing Zeng 14 , Sam Mbulaiteye 15 , Surbhi Groover 16 , Alexandra Taylor 17 , Anuja Jhingran 18 1 Radiation Oncology, Uganda Cancer Institute, Kampala, Uganda. 2 Internal Medicine, Makerere University, Kampala, Uganda. 3 Radiation Oncology, Medical College of Wisconsin, Wisconsin, USA. 4 Public Health, Mbarara University of Science and Technology, Mbarara, Uganda. 5 Global Oncology, Hutchinson Cancer Research Institute, Kampala, Uganda. 6 School of Public Health, Makerere University, Kampala, Uganda. 7 Gynaecology and Obstetrics, Makerere University, Kampala, Uganda. 8 Internal Medicine, Mbarara University of Science and Technology, Mbarara, Uganda. 9 Infectious Diseases, University of Washington, Seatle, USA. 10 Medical Oncology, Uganda Cancer Institute, Kampala, Uganda. 11 Gynaecological Oncology, Uganda Cancer Institute, Kampala, Uganda. 12 Research and Training, Uganda Cancer Institute, Kampala, Uganda. 13 Public Health, Medical College of Wisconsin, Wisconsin, USA. 14 Radiation Oncology, University of Washington, Seatle, USA. 15 Cancer Epidemiology and Genetics, National Cancer Institute, Keywords: Vaginal Stenosis Radiation Cervical Cancer 4400