ESTRO 2025 - Abstract Book

S940

Clinical – Head & neck

ESTRO 2025

Conclusion: GP IC is less toxic but is associated with more locoregional relapses than TPF. When adding IC to CCR, at least 4 courses of concomitant weekly cisplatin seem to be necessary. The debate for the best chemotherapy combinations with IMRT is still ongoing waiting for validation with prospective trials.

Keywords: Nasopharyngeal carcinoma, TPF vs GP, IMRT.

References: 1. CHEN et al. Chemotherapy in combination with radiotherapy for definitive-intent treatment of stage II-IVA nasopharyngeal carcinoma: CSCO and ASCO guideline. Journal of Clinical Oncology, 2021 2. SUN et al. Induction chemotherapy plus concurrent chemoradiotherapy versus concurrent chemoradiotherapy alone in locoregionally advanced nasopharyngeal carcinoma: a phase 3, multicentre, randomised controlled trial. The lancet 2016 3. ZHANG et al. Gemcitabine and cisplatin induction chemotherapy in nasopharyngeal carcinoma. New England Journal of Medicine, 2019 4. Chen et al. Tumor volume reduction after induction chemotherapy with gemcitabine plus cisplatin in nasopharyngeal carcinoma. Eur Arch Otorhinolaryngol. 2023

Keywords: Hypofractionation, Adjuvant radiotherapy, LMIC

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Digital Poster Management of head and neck squamous cell carcinoma with N3 nodal disease Lei Wang 1 , Linn Oo 2 , Arjun Bains 3 , Frederick Lam 4 , Arissa James 2 , Zaid Awad 5 , Dorothy Gujral 1

1 Clinical Oncology, Imperial College Healthcare NHS Trust, London, United Kingdom. 2 Oncology, Imperial College Healthcare NHS Trust, London, United Kingdom. 3 Radiation Physics and Radiobiology, Imperial College Healthcare NHS Trust, London, United Kingdom. 4 Medicine, Imperial College London, London, United Kingdom. 5 Otolaryngology, Imperial College Healthcare NHS Trust, London, United Kingdom