ESTRO 2025 - Abstract Book

S961

Clinical – Head & neck

ESTRO 2025

Conclusion: This is the largest study to date reviewing RT strategies for patients with HNSCCUP. No significant difference in the rate of primary site emergence or OS was seen. MUC had a significantly higher rate of acute and long term toxicity. These data supports INO as a suitable treatment option for unilateral HNSCCUP in the modern staging era.

Keywords: HNSCCUP, Mucosal Radiotherapy, Involved Neck Only

References: We would like to acknowledge all co-authors who contributed on behalf of the NOTCH Collaborative Group not listed on the abstract.

1209

Poster Discussion A Systematic Review and meta-analysis of the prognostic value of tumor response measurements during radiotherapy for head and neck cancers Sidsel H Poulsen 1 , Rasmus Jørgensen 1 , Jens Petersen 1,2 , Ivan R Vogelius 1 , Jeppe Friborg 1 1 Department of Oncology, Copenhagen University Hospital - Rigshospitalet, Copenhagen, Denmark. 2 Department of Computer Science, Faculty of Science, Copenhagen University, Copenhagen, Denmark Purpose/Objective: Curative radiotherapy remains the primary treatment for most locally advanced head and neck cancers. However, up to 40% of patients experience loco-regional recurrence, typically within the irradiated field 1 . Multiple methods have been studied to risk stratify patients and UICC 8 incorporated HPV status in the staging system. Other methods include tumor response measurements during radiotherapy. This systematic review and meta-analysis aim to evaluate the current literature on in-treatment tumor response assessment for locally advanced head and neck cancer.