ESTRO 2025 - Abstract Book

S978

Clinical – Head & neck

ESTRO 2025

Conclusion: The online cognitive battery was well received with an overall positive user experience reported. Cost effective, efficient and user-acceptable evaluation methods of NCF, such the ACS, are important if the neurocognitive impact of cancer treatments is going to be more widely assessed in research settings.

Keywords: Oropharyngeal CA, Neurocognition, Radiotherapy

References: [1] Okuyemi OT. Effect of Cognition on Quality of Life After Head and Neck Cancer Treatment. JAMA Otolaryngology– Head & Neck Surgery. 2016;142:1152-3. [2] Iyizoba-Ebozue Z, Prestwich R, Brown S, Hall E, Lilley J, Lowe M, et al. Neurocognitive function following (chemo)radiotherapy for nasopharyngeal cancer and other head and neck cancers: A systematic review. Radiother Oncol. 2023;188:109863. [3] Chow JCH, Lee J, Lai MMP, Li S, Lau AMC, Ng BSY, et al. Multi-domain neurocognitive impairment following definitive intensity-modulated radiotherapy for nasopharyngeal cancer: A cross-sectional study. Radiother Oncol. 2024;193:110143.

1383

Digital Poster Exploring Gender-Specific Nutritional Disparities in Head and Neck Cancer Patients Treated with (Chemo)Radiotherapy Anastassia Löser 1 , Rouzbeh Zohri 2 , Lorenz Hahn 3 , Niloufar Seyedi 4 , Cordula Petersen 5 , Jakob Abel 6 , Laura Magdalena Kutz 6 , Andreas Krüll 5 , Dirk Rades 1 1 Department of Radiotherapy, University Medical Center Schleswig-Holstein (Campus Lübeck), Lübeck, Germany. 2 Department of Osteology, Outpatient Center of the University Medical Center Hamburg-Eppendorf, Hamburg, Germany. 3 Tetra Pak Processing GmbH, Exploring Gender-Specific Nutritional Disparities in Head and Neck Cancer Patients Treated with (Chemo)Radiotherapy, Hamburg, Germany. 4 Department of Stem Cell Transplantation, University Medical Center Hamburg-Eppendorf, Hamburg, Germany. 5 Department of Radiotherapy, University Medical Center Hamburg-Eppendorf, Hamburg, Germany. 6 Department of Radiotherapy, Outpatient Center of the University Medical Center Hamburg-Eppendorf, Hamburg, Germany Purpose/Objective: This study investigates gender-specific disparities in nutritional status, body weight changes, and their influence on overall survival (OS) in head and neck cancer (HNC) patients treated with (chemo)radiotherapy (CRT). Material/Methods: Between 2018 and 2020, 61 HNC patients (17 female, 44 male) were prospectively included to undergo curative CRT. Nutritional evaluations comprised dietary questionnaires and records, anthropometric measurements (body mass index [BMI], body composition via bioelectrical impedance analysis [BIA]), and biomarker analyses such as albumin and CRP. Assessments were carried out at baseline, during, and after CRT. Results: Baseline assessments revealed gender-specific differences in Karnofsky Performance Status (p=0.01), daily caloric intake (p=0.04), phase angle (PA) (p=0.003), and fat-free mass index (FFMI) (p<0.001). During CRT, males experienced a significantly greater increase in caloric deficit (p<0.001) and more substantial reductions in BMI, FFMI, and PA compared to females. The risk of malnutrition (MUST score) significantly increased in males (p=0.008) but remained unchanged in females. While both genders showed decreases in albumin and total protein levels, the decline in albumin was more pronounced in females. Survival analysis showed that baseline factors such as caloric deficit, BMI, PA, and FFMI were predictive of survival in