ESTRO 35 Programme book

Symposium WBRT FOR BRAINMETASTASES- THE END OF AN ERA? 09:15 - 10:30 | GIALLA

This session will address an actual outline of the efficacy of whole brain radiotherapy (WBRT) in the treatment of multiple brain metastases. First speaker, Paula Mulvenna, will give an overview of WBRT including history, aims and toxicities. Additionally, she will shortly present the outcomes of the MRC QUARTZ trial. Luis Schiappacasse will address the role of stereotactic radiosurgery to treat limited and extensive brain metastases especially in conjunction with WBRT. Finally, Rafal Dziadziuszko will present systemic therapies for the treatment of brain metastases originated from lung and breast cancer with focus on chemotherapy alone or in combination with radiotherapy. Chair: B. Timmermann (Germany) Co-chair: D. Greto (Italy)

TUESDAY 3 MAY 2016

09:15 > Whole brain radiotherapy for brain metastases - the end of an era? Speaker: P. Mulvenna (UK)

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09:40 > Focal radiotherapy for multiple brain metastases Speaker: L. Schiappacasse (Switzerland)

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10:05 > Role of systemic therapy in the treatment of brain metastases Speaker: R. Dziadziuszko (Poland)

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Symposium RADIOTHERAPY “AUTOVACCINATION”; WITH SYSTEMIC IMMUNE MODULATORS FOR MODERN IMMUNOTHERAPY 09:15 - 10:30 | ROOM 4 The current understanding of the impact of radiation therapy on anti tumour immunity has changed our understanding of tumour resistance to radiotherapy which is no longer perceived as the only conse- quence of tumour cells intrinsic clonogenic resistance to cell kill. The interplay between tumour cells and the immune stroma is influenced by cell death triggered by irradiation which dictates the immunological response. Immune checkpoints inhibitors may increase tumour response and also propagate systemic anti tumour immune response thus converting the

tumour into an immunogenic hub. Chair: E. Deutsch (France) Co-chair: M. Trovo (Italy)

09:15 > Should the combined treatment be part of our field of knowledge? The 5 th ‘R’ (immune-mediated) rejection of radiobiology Speaker: P.C. Lara Jimenez (Spain) 09:40 > Radiotherapy for immunotherapy: optimising the doses and fractiona- tion Speaker: S. Demaria (USA)

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INTERDISCIPLINARY RADIOBIOLOGY

CLINICAL BRACHYTHERAPY PHYSICS

RTT

YOUNG

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