ESTRO 36 Abstract Book

S580 ESTRO 36 2017 _______________________________________________________________________________________________

Fig. 1: Web-based decision aid tool for advanced larynx cancer patients

results than T1 or T0is stage group in terms of OS (p 0,001) regardless of treatment used. There weren´t no differences in terms of toxicity nor local control between elderly pts and young pts regardless of treatment used either. EP-1063 Epidemiology and clinical outcome of HPV in different head and neck cancer a subgroup analysis E. Boelke 1 , B. Gössler 1 , B. Tamaskovic 1 , W. Budach 1 , C. Matuschek 1 1 University Hospital Düsseldorf Heinrich Heine University Düsseldorf, Radiation Oncology, Düsseldorf, Germany Purpose or Objective Human papillomavirus (HPV)-associated squamous cell carcinoma of the oropharynx is a well-defined disease typically affecting young to middle-aged male non- smokers. The incidence of HPV-associated oropharyngeal cancers is rapidly increasing in most Western countries, but detailed epidemiological data are not available for the Dusseldorf population. Moreover, among other head and neck regions, a less significant proportion of oral high- grade dysplasia and cancers appears to depend on HPV infection, whereas its role in laryngeal cancer is recognized as less significant. The aim of this study was to find out the incidence and clinical outcome of HPV infection in different head neck cancer patients in a German population. Material and Methods In this retrospective study, the tumour tissue from 164 patients (110 men, 54 women, 62.8 years + 12.7) with head neck cancer (oropharynx = 65 nasopharynx = 10, larynx = 13, hypopharynx = 15, oral cavity = 33 CUP = 5, Other = 23) were tested for HPV infection. Furthermore, the clinical outcome for all tumor sides was examined with uni and multivariate analysis. We analyzed p16 in all tumor tissues as a surrogate marker for HPV infection with immunohistochemistry. Moreover, risk factors such as nicotine, alcohol abuse, location of the tumour, resection margin of the tumour tissue, histology, lymph nodes involvement, extracapsular spread, tumour stage, and the treatment of the tumour (surgery, chemo and radiation therapy) were examined for local tumour control and overall survival for all patients. Results The prevalence of HPV infection in oropharynx-carcinoma patients in Dusseldorf was 33%. Patients with HPV-positive oropharyngeal carcinomas showed a tendency towards longer survival time, (p = 0.76, HR: 2.42, 95% CI 0.91 - 6.44) compared to HPV-negative tumours. This association was independent from alcohol and nicotine abuse. Other tumour locations like larynx or hypopharynx carcinoma showed no association between HPV infection and clinical outcome. As expected the tumour stage in all tumour locations was significant in the uni and multivariate analysis for local control and overall survival. Conclusion The HPV infection in Dusseldorf was lower than anticipated. Furthermore, in our study it seems that p 16 positive oropharyngeal carcinoma patients have a better clinical outcome than p 16 negative patients. In this patient group p 16 can be used as a prognostic biomarker. This was independent from alcohol and nicotine abuse. But for other tumor localizations we could not find a better clinical outcome. EP-1064 Does parotid sparing adaptive radiotherapy (PSART) benefit patients? Interim results of PARITY study M. Arunsingh 1 , C. Nallathambi 1 , S. Prasath 1 , A. Balakrishnan 1 , R.K. Shrimali 1 , R. Achari 1 , I. Mallick 1 , S. Chatterjee 1 1 Tata Medical Center, Department of Radiation Oncology, Kolkata, India

Conclusion A systematic validation process, as IPDAS, makes it possible to understand the characteristics and decisional needs of patients and clinicians, which are specific and differ among diseases and contexts. This is essential for implementation of PDAs in the clinical practice. EP-1062 Hypofractionated vs standard radical radiotherapy in early (T1-T2) glottic cancer patients. M.A. González Ruiz 1 , J.J. Cabrera Rodríguez 1 , A. Ruiz Herrero 1 , M.C. Cruz Muñoz 1 , P. Simón Silva 1 , J. Quirós Rivero 1 , J.L. Muñoz García 1 , Y. Ríos Kavadoy 1 , M.F. Ropero Carmona 1 , F. García Urra 1 1 Infanta Cristina Hospital, Radiation Oncology, Badajoz, Spain Purpose or Objective To analyze the results [(disease free survival (DFS) and overall survival (OS)] of patients (pts) with glottic cancer (GC) treated with hypofractionated radiation therapy versus standard radiotherapy treatment with radical intention. Material and Methods Retrospective comparative study of 125 pts with GC T1 or T0is stage (119 pts) and T2 stage (6 pts) treated with radical intention with radiation therapy in our hospital from June 1995 to June 2015. Hypofractionated treatment (2,25 Gy/fraction; total dose 63 Gy) was used in 42 pts and standard treatment (2 Gy/fraction; total dose 70 Gy) was used in 83 pts. Baseline characteristic were similar in both groups. Median total dose of radiotherapy was 66 Gy (range 63-70). Kaplan-Meier curves have been used for the statistical analysis of survival and the log-rank test for the comparison of the survivals. Treatment-related toxicity was assessed using RTOG and the NCI-Common Terminology Criteria for Adverse Events guidelines. Results The median follow-up was 215 months. The DFS and OS in hypofractionated group were 97,6% and 93% respectively and in standard radiotherapy group were 93% and 95,2% respectively without statistically significant differences. When we analyzed OS by stage subgroups, we can see that in T1 or T0is group the results are better (95,8%) than in T2 group 66,7% (p 0,001) without differences because of the treatment regimen used. In the analysis according to the age of the pts, we had the following results in terms of OS: < 70 years-old pts treated with hypofractionated treatment (28 pts) were 96,4 % and >70 years-old pts (14 pts) were 100%. The OS in < 70 years-old pts treated with standard treatment (43 pts) was 93% and in >70 years-old pts (40 pts) was 92,5% without statistically significant differences. When we analyze OS according to the anterior commissure involvement, we haven´t found statistically significant differences. In both groups the majority of pts had acute skin and mucosa toxicity grade 1-2 without statistically significant differences regardless the regimen of treatment used. Conclusion Hypofractionated treatment supposed better local disease control than standard treatment but in terms of OS there weren´t any differences. When we analized our pts by subgroups stage, we found that T2 stage group had worse